Dissection of the gut microbiota in mothers and children with chronic Trichuris trichiura infection in Pemba Island, Tanzania.
Dissection of the gut microbiota in mothers and children with chronic Trichuris trichiura infection in Pemba Island, Tanzania.
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DOI：
10.1186/s13071-021-04580-1
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发表时间：
2021-01-19
影响因子：
3.2
通讯作者：
Miceli C
中科院分区：
文献类型：
--
作者：
Chen H;Mozzicafreddo M;Pierella E;Carletti V;Piersanti A;Ali SM;Ame SM;Wang C;Miceli C
土壤传播的蠕虫病是重要的被忽视的热带病，在世界范围内导致大量的残疾调整生命年。刻画人类肠道微生物群与蠕虫之间的相互作用，对于开发不依赖于化疗且不会导致耐药性的替代治疗具有重要意义。我们收集了奔巴岛32对母亲和儿童的粪便样本，并使用16S rRNA基因测序对其肠道微生物群进行了监测。我们观察到，受感染的母亲和儿童的肠道微生物群发生了变化。一些产生短链脂肪酸（SCFA）的细菌和碳水化合物降解细菌在感染个体中表现出较低的丰度。感染母亲体内潜在致病性弯曲杆菌和促炎的甲烷前细菌以及感染儿童体内机会性肠球菌的丰度更高。我们的研究结果可以揭示毛虫感染个体的微生物群特征，提示关键微生物群在宿主中的潜在作用，并有助于制定新的控制毛虫感染的策略。
Soil-transmitted helminthiases are important neglected tropical diseases that result in a notably high number of disability-adjusted life years worldwide. Characterizing the interactions between the human intestinal microbiome and helminths is of interest in the development of alternative treatments that do not rely on chemotherapeutics and do not lead to drug resistance. We recruited and obtained fecal samples from 32 pairs of mothers and children on Pemba Island and monitored their intestinal microbiota using 16S rRNA gene sequencing. We observed that microbial changes occur in the gut microbiota of infected mothers and children. Some short-chain fatty acid (SCFA)-producing bacteria and carbohydrate-degrading bacteria exhibited lower abundance in the infected individuals. Potentially pathogenic Campylobacter and proinflammatory Methanobrevibacter in infected mothers and opportunistic Enterococcus in infected children exhibited greater abundance. Our findings could reveal the microbiota profiling in T. trichiura-infected individuals, indicate the potential roles of key microbiota in the host and aid to the development of novel strategies to control T. trichiura infection.
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DOI：
10.1098/rstb.2014.0296
发表时间：
2015-08-19
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Giacomin P;Croese J;Krause L;Loukas A;Cantacessi C
通讯作者：
Cantacessi C
影响因子：
4.6
作者：
Giacomin P;Zakrzewski M;Jenkins TP;Su X;Al-Hallaf R;Croese J;de Vries S;Grant A;Mitreva M;Loukas A;Krause L;Cantacessi C
通讯作者：
Cantacessi C
影响因子：
3.3
作者：
Geerts, S;Gryseels, B
通讯作者：
Gryseels, B
影响因子：
5.4
作者：
Dicks, L. M. T.;Botes, M.
通讯作者：
Botes, M.
影响因子：
4
作者：
Jiang, Hai-yan;Zhao, Na;Zhang, Xi-chen
通讯作者：
Zhang, Xi-chen