Effects of aging, high-fat diet, and testosterone treatment on neural and metabolic outcomes in male brown Norway rats.
Effects of aging, high-fat diet, and testosterone treatment on neural and metabolic outcomes in male brown Norway rats.
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DOI：
10.1016/j.neurobiolaging.2018.09.016
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发表时间：
2019-01
影响因子：
4.2
通讯作者：
Pike CJ
中科院分区：
文献类型：
--
作者：
Moser VA;Christensen A;Liu J;Zhou A;Yagi S;Beam CR;Galea L;Pike CJ
阿尔茨海默病（AD）的风险受到多种因素的影响，包括衰老，肥胖和低睾酮。我们以前表明，肥胖和低睾酮独立和交互加剧AD相关的结果在年轻的成年啮齿动物。目前研究的目的有两个：检查致肥胖饮食的影响是否随年龄的增加而不同，并确定中年和老年动物的睾酮治疗是否减轻了饮食的负面影响。雄性棕色挪威大鼠从青年、中年或老年开始维持对照或高脂肪饮食12周。在饮食操作期间，对中年和老年动物的单独队列进行睾酮处理。终点包括代谢指标、炎症、认知能力和神经健康结果。衰老与较差的结果有关，这些结果通常因高脂肪饮食而加剧，特别是在中年。替吉奥治疗在很大程度上是没有好处的，只对选定的一些措施产生微妙的影响。了解肥胖的有害影响如何受到年龄增长的影响，以及睾酮等保护性策略减少这些影响的能力，可能会对年龄相关的认知能力下降和AD的发展和预防提供重要的见解。
Risk for Alzheimer’s disease (AD) is affected by multiple factors, including aging, obesity, and low testosterone. We previously showed that obesity and low testosterone independently and interactively exacerbate AD-related outcomes in young adult rodents. The goals of the current study are two-fold: to examine whether the effects of obesogenic diet differ with increasing age, and to determine if testosterone treatment in middle-aged and aged animals mitigates negative effects of diet. Male brown Norway rats were maintained on control or high-fat diets for 12 weeks beginning in young adulthood, middle-age, or advanced age. Separate cohorts of middle-aged and aged animals were treated with testosterone during dietary manipulations. Endpoints included metabolic indices, inflammation, cognitive performance, and neural health outcomes. Aging was associated with poorer outcomes that were generally exacerbated by high fat diet, especially at middle-age. Testosterone treatment was largely without benefit, exerting only subtle effects on a select number of measures. Understanding how the deleterious effects of obesity are affected by advancing age and the ability of protective strategies such as testosterone to reduce these effects may provide significant insight into both the development and prevention of age-related cognitive decline and AD.
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影响因子：
3.7
作者：
Barron AM;Rosario ER;Elteriefi R;Pike CJ
通讯作者：
Pike CJ
影响因子：
13.6
作者：
Freund A;Orjalo AV;Desprez PY;Campisi J
通讯作者：
Campisi J
影响因子：
9.3
作者：
De Luca SN;Ziko I;Sominsky L;Nguyen JC;Dinan T;Miller AA;Jenkins TA;Spencer SJ
通讯作者：
Spencer SJ
影响因子：
9.9
作者：
Cournot, M.;Marquie, J. -C.;Ruidavets, J. -B.
通讯作者：
Ruidavets, J. -B.
影响因子：
4.2
作者：
Elias, MF;Elias, PK;D'Agostino, RB
通讯作者：
D'Agostino, RB