Fecal Microbial Community Composition in Myeloproliferative Neoplasm Patients Is Associated with an Inflammatory State.
Fecal Microbial Community Composition in Myeloproliferative Neoplasm Patients Is Associated with an Inflammatory State.
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DOI：
10.1128/spectrum.00032-22
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发表时间：
2022-06-29
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
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作者：
人类微生物组在癌症背景下调节炎症的能力变得越来越清楚。骨髓增生性肿瘤 (MPN) 是一种慢性血液系统恶性肿瘤，其中炎症在疾病的发生、进展和症状中发挥着关键作用。为了更好地了解 MPN 患者肠道微生物组的组成，我们从 25 名 MPN 患者和 25 名非 MPN 对照中收集了三次粪便样本。尽管微生物群落组成之间的大部分差异可归因于个体（方差排列分析 [PERMANOVA]，R2 = 0.92，P = 0.001），但 1.7% 的差异可归因于疾病状态（MPN 与非 MPN）。当进行更详细的分析时，在 MPN 中发现映射到 Phascolarctobacter 菌（一种以前与减少炎症相关的微生物）的读数显着减少。此外，我们的数据揭示了副拟杆菌和肿瘤坏死因子 α (TNF-α) 之间的关联，肿瘤坏死因子 α 是一种在 MPN 中升高的炎症细胞因子。综上所述，我们的结果表明，与非 MPN 对照相比，MPN 患者的微生物组存在显着差异，并且我们确定了可能在该疾病核心慢性炎症中发挥作用的特定物种。重要性 MPN 是慢性血癌，炎症在疾病的发生、进展和症状中发挥着关键作用。肠道微生物组调节正常的血液发育和炎症，也可能影响血癌的发展和表现。因此，微生物组可能是 MPN 炎症的重要调节剂，并且有可能在这种疾病的治疗中发挥作用。然而，肠道微生物组和 MPN 之间的关系尚未明确。因此，我们对 MPN 微生物组进行了评估，比较了 MPN 患者与健康捐赠者以及不同疾病状态的 MPN 患者之间的微生物组。
The capacity of the human microbiome to modulate inflammation in the context of cancer is becoming increasingly clear. Myeloproliferative neoplasms (MPNs) are chronic hematologic malignancies in which inflammation plays a key role in disease initiation, progression, and symptomatology. To better understand the composition of the gut microbiome in patients with MPN, triplicate fecal samples were collected from 25 MPN patients and 25 non-MPN controls. Although most of the variance between the microbial community compositions could be attributed to the individual (permutational analysis of variance [PERMANOVA], R2 = 0.92, P = 0.001), 1.7% of the variance could be attributed to disease status (MPN versus non-MPN). When a more detailed analysis was performed, significantly fewer reads mapping to a species of Phascolarctobacterium, a microbe previously associated with reduced inflammation, were found in MPNs. Further, our data revealed an association between Parabacteroides and tumor necrosis factor alpha (TNF-α), an inflammatory cytokine elevated in MPNs. Taken together, our results indicate a significant difference in the microbiome of MPN patients compared to non-MPN controls, and we identify specific species which may have a role in the chronic inflammation central to this disease. IMPORTANCE MPNs are chronic blood cancers in which inflammation plays a key role in disease initiation, progression, and symptomatology. The gut microbiome modulates normal blood development and inflammation and may also impact the development and manifestation of blood cancers. Therefore, the microbiome may be an important modulator of inflammation in MPN and could potentially be leveraged therapeutically in this disease. However, the relationship between the gut microbiome and MPNs has not been defined. Therefore, we performed an evaluation of the MPN microbiome, comparing the microbiomes of MPN patients with healthy donors and between MPN patients with various states of disease.
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影响因子：
4.7
作者：
Barone M;Barone M;Ricci F;Auteri G;Corradi G;Fabbri F;Papa V;Bandini E;Cenacchi G;Tazzari PL;Vianelli N;Turroni S;Cavo M;Palandri F;Candela M;Catani L
通讯作者：
Catani L
影响因子：
11
作者：
Citronberg, Jessica S.;Curtis, Keith R.;Hullar, Meredith A. J.
通讯作者：
Hullar, Meredith A. J.
影响因子：
17.1
作者：
Vila, Arnau Vich;Imhann, Floris;Weersma, Rinse K.
通讯作者：
Weersma, Rinse K.
影响因子：
4.6
作者：
Dashnyam P;Mudududdla R;Hsieh TJ;Lin TC;Lin HY;Chen PY;Hsu CY;Lin CH
通讯作者：
Lin CH
影响因子：
30.3
作者：
Staffas A;Burgos da Silva M;Slingerland AE;Lazrak A;Bare CJ;Holman CD;Docampo MD;Shono Y;Durham B;Pickard AJ;Cross JR;Stein-Thoeringer C;Velardi E;Tsai JJ;Jahn L;Jay H;Lieberman S;Smith OM;Pamer EG;Peled JU;Cohen DE;Jenq RR;van den Brink MRM
通讯作者：
van den Brink MRM