Trajectory and correlates of growth of extremely-low-birth-weight adolescents.
Trajectory and correlates of growth of extremely-low-birth-weight adolescents.
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DOI：
10.1038/pr.2013.209
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发表时间：
2014-02
影响因子：
3.6
通讯作者：
Cuttler, Leona
中科院分区：
文献类型：
--
作者：
Hack, Maureen;Schluchter, Mark;Margevicius, Seunghee;Andreias, Laura;Taylor, H. Gerry;Cuttler, Leona
追赶型生长可能导致肥胖和代谢后遗症。我们试图研究极低出生体重（ELBW, <1 kg）青少年的生长轨迹和追赶的相关因素。1992 ~ 1995年出生的148例神经功能正常的低体重儿和115例正常出生体重（NBW）对照的队列研究。ELBW儿童从出生开始的性别特异性生长的纵向测量，以及ELBW和NBW儿童14岁时的生长和肥胖测量。新生儿生长衰竭后，ELBW儿童的生长速度加快，但在8岁时，他们的体重和身高z得分仍低于NBW儿童。到14岁时，ELBW男孩已经赶上了他们的NBW对照组，但ELBW女孩仍然明显更小。然而，低体重儿童在肥胖测量方面与对照组没有差异。在分层多元回归分析中，只有母亲的BMI和婴儿期和儿童期的体重增加能预测ELBW儿童14岁体重z评分、BMI z评分和腹围。围产期危险因素包括宫内生长只能预测到20个月的生长。母亲的体重指数和生长速度，而不是围产期因素，预测14年肥胖在神经正常的ELBW青少年。
Catch-up growth may predispose to obesity and metabolic sequelae. We sought to examine the trajectory and correlates of growth and catch-up among extremely low birth weight (ELBW, <1 kg) adolescents. Cohort study of 148 neurologically normal ELBW children and 115 normal birth weight (NBW) controls born 1992 through 1995. Longitudinal measures of gender-specific growth of ELBW children from birth, and growth and measures of obesity of ELBW and NBW children at 14 years. Following neonatal growth failure, ELBW children had accelerated growth, but at 8 years they still had lower weight and height z scores than NBW children. By 14 years ELBW boys had caught up in growth to their NBW controls but ELBW girls remained significantly smaller. ELBW children however did not differ from their controls in measures of obesity. In hierarchical multiple regression analyses only maternal BMI and weight gain during infancy and childhood predicted the ELBW children’s 14-year weight z scores, BMI z scores and abdominal circumference. Perinatal risk factors including intrauterine growth only predicted growth up to 20 months. Maternal BMI and rate of growth, rather than perinatal factors, predict 14-year obesity among neurologically normal ELBW adolescents.
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