PATET ratio by Doppler echocardiography: noninvasive detection of pediatric pulmonary arterial hypertension.
PATET ratio by Doppler echocardiography: noninvasive detection of pediatric pulmonary arterial hypertension.
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DOI：
10.1038/s41390-021-01840-9
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发表时间：
2022-09
影响因子：
3.6
通讯作者：
Malbrue, Raphael A.
中科院分区：
文献类型：
--
作者：
Trittmann, Jennifer K.;Almazroue, Hanadi;Nelin, Leif D.;Shaffer, Terri A.;Celestine, Charanda R.;Green, Henry W., III;Malbrue, Raphael A.
肺动脉加速时间 (PAT) 和 PAT:射血时间 (PATET) 比率是肺动脉高压 (PAH) 的超声心动图测量值。这些非侵入性定量测量非常适合纵向追踪 PAH 的临床病程，特别是因为它与治疗需求和/或治疗反应有关。本文重点介绍婴儿和儿童 PATET 测量的最新文献，因为它与 PAH 中 PATET 比率的缩短有关。与此同时，进一步开发 PATET 作为临床前模型（特别是小鼠）中 PAH 的结果测量，以便该领域可以向安全有效的人类临床研究迈进。在这里，我们介绍有关婴儿和儿童 PATET 的已知信息，并讨论临床前模型中的已知信息，特别强调新生小鼠模型。在动物模型和人类疾病中，PATET 允许对同一个体进行纵向测量，从而更精确地确定疾病/模型进展和/或对治疗的反应。
Pulmonary artery acceleration time (PAT) and PAT: ejection time (PATET) ratio are echocardiographic measurements of pulmonary arterial hypertension (PAH). These non-invasive quantitative measurements are ideal to follow longitudinally through the clinical course of PAH, especially as it relates to need for and/or response to treatment. This review article focuses on the current literature of PATET measurement for infants and children as it relates to shortening of the PATET ratio in PAH. At the same time, further development of PATET as an outcome measure for PAH in pre-clinical models, particularly mice, such that the field can move forward to human clinical studies that are both safe and effective. Here we present what is known about PATET in infants and children and discuss what is known in pre-clinical models with particular emphasis on neonatal mouse models. In both animal models and human disease, PATET allows for longitudinal measurements in the same individual, leading to more precise determinations of disease/model progression and/or response to therapy.
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影响因子：
3.6
作者：
de Boode WP;Singh Y;Molnar Z;Schubert U;Savoia M;Sehgal A;Levy PT;McNamara PJ;El-Khuffash A;European Special Interest Group ‘Neonatologist Performed Echocardiography’ (NPE)
通讯作者：
European Special Interest Group ‘Neonatologist Performed Echocardiography’ (NPE)
影响因子：
9.8
作者：
Fuke, S;Kanzaki, T;Murata, Y
通讯作者：
Murata, Y
影响因子：
9.6
作者：
GARDIN, JM;SATO, DA;HENRY, WL
通讯作者：
HENRY, WL
DOI：
10.1136/adc.68.3_spec_no.303
发表时间：
1993-03-01
影响因子：
4.4
作者：
GILL, AB;WEINDLING, AM
通讯作者：
WEINDLING, AM
影响因子：
1.5
作者：
Badea, CT;Bucholz, E;Johnson, GA
通讯作者：
Johnson, GA