Effects of silica and zinc oxide doping on mechanical and biological properties of 3D printed tricalcium phosphate tissue engineering scaffolds.
Effects of silica and zinc oxide doping on mechanical and biological properties of 3D printed tricalcium phosphate tissue engineering scaffolds.
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DOI：
10.1016/j.dental.2011.09.010
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发表时间：
2012-02
期刊：
影响因子：
5
通讯作者：
Bose, Susmita
中科院分区：
文献类型：
--
作者：
Fielding, Gary A.;Bandyopadhyay, Amit;Bose, Susmita
关键词：
研究了SiO2（0.5wt%）和ZnO（0.25wt%）掺杂对三维多孔磷酸三钙（TCP）支架力学性能和生物学性能的影响。支架是用商业3D打印机制作的。烧结后的相分析通过x射线衍射测定。通过场发射电子显微镜检查支架的表面形态。机械强度用螺杆驱动万能试验机评价。MTT法检测细胞增殖特性，场发射电镜观察细胞形态。向TCP中添加掺杂剂使纯TCP的平均密度从90.8 ± 0.8%增加到94.1 ± 1.6%，并延缓了高烧结温度下β向α的相变，从而使抗压强度增加了2.5倍。使用hFOB细胞进行的体外细胞-材料相互作用研究证实，与纯TCP支架相比，向支架中添加SiO2和ZnO有助于更快的细胞增殖。向TCP支架添加SiO2和ZnO掺杂剂显示出增加的机械强度以及增加的细胞增殖。
To evaluate the effects of SiO2 (0.5 wt %) and ZnO (0.25 wt %) dopants on the mechanical and biological properties of tricalcium phosphate (TCP) scaffolds with three dimensionally (3D) interconnected pores. Scaffolds were created with a commercial 3D printer. Post sintering phase analysis was determined by x-ray diffraction. Surface morphology of the scaffolds was examined by field emission electron microscopy. Mechanical strength was evaluated with a screw driven universal testing machine. MTT assay was used for cellular proliferation characteristics and cellular morphology was examined by field emission electron microscopy. Addition of dopants into TCP increased the average density of pure TCP from 90.8 ± 0.8% to 94.1 ± 1.6% and retarded the β to α phase transformation at high sintering temperatures, which resulted in up to 2.5 fold increase in compressive strength. In vitro cell-materials interaction studies, carried out using hFOB cells, confirmed that the addition of SiO2 and ZnO to the scaffolds facilitates faster cell proliferation when compared to pure TCP scaffolds. Addition of SiO2 and ZnO dopants to the TCP scaffolds showed increased mechanical strength as well as increased cellular proliferation.
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