Hippocampal dysfunction during declarative memory encoding in schizophrenia and effects of genetic liability.
Hippocampal dysfunction during declarative memory encoding in schizophrenia and effects of genetic liability.
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DOI：
10.1016/j.schres.2014.11.030
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发表时间：
2015-02
影响因子：
4.5
通讯作者：
Narr, Katherine L.
中科院分区：
文献类型：
--
作者：
Pirnia, Tara;Woods, Roger P.;Hamilton, Liberty S.;Lyden, Hannah;Joshi, Shantanu H.;Asarnow, Robert F.;Nuechterlein, Keith H.;Narr, Katherine L.
据报道，精神分裂症患者和患者未受影响的生物亲属中存在陈述性记忆（DM）障碍。然而，由内侧颞叶（MTL）记忆系统介导的成功和不成功编码的神经相关性以及疾病相关遗传易感性的影响仍在探索中。本研究采用事件相关的功能磁共振成像模式，比较激活成功和不成功的编码联想面孔名称刺激之间的26例精神分裂症患者（平均年龄：33，19 m/7 f），30名对照组（平均年龄：29，24 m/6 f）和14名未受影响的亲属（平均年龄：40，5 m/9 f）。与对照组或未受影响的亲属相比，当将成功编码的事件与固定进行对比时，患者的腹侧视觉流和颞顶叶皮质关联区显示出过度激活。后续海马区的利益分析显示，精神分裂症相关的过度激活在右前海马在成功的编码;对比成功与不成功的事件产生精神分裂症相关的低激活在左前海马。在成功与不成功的编码过程中，在未受影响的亲属中观察到类似的海马低激活。海马体积的事后分析显示，与对照组相比，患者减少，但未受影响的亲属没有减少。研究结果表明，DM编码缺陷可归因于影响MTL记忆系统不同组成部分的疾病特异性和遗传易感性因素。仅在患者中观察到的颞枕和顶叶区域的过度激活表明疾病相关因素的影响。区域性高激活和低激活归因于成功的编码发生在患者和未受影响的亲属表明精神分裂症相关的遗传易感性因素的影响。
Declarative memory (DM) impairments are reported in schizophrenia and in unaffected biological relatives of patients. However, the neural correlates of successful and unsuccessful encoding, mediated by the medial temporal lobe (MTL) memory system, and the influence of disease-related genetic liability remain under explored. This study employed an event-related functional MRI paradigm to compare activations for successfully and unsuccessfully encoded associative face-name stimuli between 26 schizophrenia patients (mean age: 33, 19m/7f), 30 controls (mean age: 29, 24m/6f) and 14 unaffected relatives of patients (mean age: 40, 5m/9f). Compared to controls or unaffected relatives, patients showed hyper-activations in ventral visual stream and temporo-parietal cortical association areas when contrasting successfully encoded events to fixation. Follow-up hippocampal regions-of-interest analysis revealed schizophrenia-related hyper-activations in the right anterior hippocampus during successful encoding; contrasting successful versus unsuccessful events produced schizophrenia-related hypo-activations in the left anterior hippocampus. Similar hippocampal hypo-activations were observed in unaffected relatives during successful versus unsuccessful encoding. Post-hoc analyses of hippocampal volume showed reductions in patients, but not in unaffected relatives compared to controls. Findings suggest that DM encoding deficits are attributable to both disease-specific and genetic liability factors that impact different components of the MTL memory system. Hyper-activations in temporo-occipital and parietal regions observed only in patients suggest the influence of disease-related factors. Regional hyper- and hypo-activations attributable to successful encoding occurring in both patients and unaffected relatives suggest the influence of schizophrenia-related genetic liability factors.
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影响因子：
5.6
作者：
Bearden, Carrie E.;Karlsgodt, Katherine H.;Glahn, David C.
通讯作者：
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DOI：
10.1073/pnas.95.3.891
发表时间：
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影响因子：
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作者：
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