Negative urgency and ventromedial prefrontal cortex responses to alcohol cues: FMRI evidence of emotion-based impulsivity.
Negative urgency and ventromedial prefrontal cortex responses to alcohol cues: FMRI evidence of emotion-based impulsivity.
复制标题
DOI：
10.1111/acer.12266
复制
发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Kareken DA
中科院分区：
文献类型：
--
作者：
Cyders MA;Dzemidzic M;Eiler WJ;Coskunpinar A;Karyadi K;Kareken DA
最近的研究强调了基于情绪的冲动(消极和积极的紧迫感人格特征)在饮酒和滥用中的作用，但尚未研究这些人格特征如何与大脑的动机系统相互作用。使用功能磁共振成像(FMRI)，我们测试了紧迫感特征和情绪诱导是否影响了内侧前额叶对酒精气味的反应(ACO)。27名社交饮酒者(平均年龄25.2岁，14名男性)在间歇性接触ACO和食欲控制(AppCo)香气期间进行了6次fMRI扫描，同时观看负面、中性或积极的情绪图像(3种情绪状况)。体素分析(p<；0.001)证实内侧前额叶(MPFC)和腹内侧前额叶(VmPFC)的[Aco>；AppCo]激活。从先验的mPFC和vmPFC区域提取，并在Odor(Aco，AppCo)×情绪因子模型中分析，在左侧vmPFC(p<；0.001)、左侧mPFC(p=0.002)和右侧vmPFC(p=0.002)区域，ACo的激活程度大于AppCo。情绪与激活没有显著的交互作用，但特质消极紧迫感的协变量解释了左侧vmPFC(p=0.01)和右侧vmPFC(p=0.01)[ACO>；AppCo]激活的显著差异。消极紧迫感也在vmPFC激活与(1)主观渴望和(2)问题饮酒之间的关系中起中介作用。消极紧迫感的特征与vmPFC中对酒精暗示的神经反应有关，vmPFC是一个涉及奖励价值和情绪引导决策的区域。这表明，消极的紧迫感可能会改变主观渴望和大脑中参与编码奖赏价值的区域。
Recent research has highlighted the role of emotion-based impulsivity (negative and positive urgency personality traits) for alcohol use and abuse, but has yet to examine how these personality traits interact with the brain’s motivational systems. Using functional magnetic resonance imaging (fMRI), we tested if urgency traits and mood induction affected medial prefrontal responses to alcohol odors (AcO). Twenty seven social drinkers (mean age = 25.2, 14 males) had six fMRI scans while viewing negative, neutral, or positive mood images (3 mood conditions) during intermittent exposure to AcO and appetitive control (AppCo) aromas. Voxel-wise analyses (p < 0.001) confirmed [AcO > AppCo] activation throughout medial (mPFC) and ventromedial prefrontal regions (vmPFC). Extracted from a priori mPFC and vmPFC regions, and analyzed in Odor (AcO, AppCo) × Mood factorial models, AcO activation was greater than AppCo in left vmPFC (p < 0.001), left mPFC (p = 0.002), and right vmPFC (p = 0.01) regions. Mood did not interact significantly with activation but the covariate of trait negative urgency accounted for significant variance in left vmPFC (p = 0.01) and right vmPFC (p = 0.01) [AcO > AppCo] activation. Negative urgency also mediated the relationship between vmPFC activation and both (1) subjective craving and (2) problematic drinking. The trait of negative urgency is associated with neural responses to alcohol cues in the vmPFC, a region involved in reward value and emotion-guided decision-making. This suggests that negative urgency might alter subjective craving and brain regions involved in coding reward value.
登录
查看更多内容
影响因子：
56.9
作者：
Hare, Todd A.;Camerer, Colin F.;Rangel, Antonio
通讯作者：
Rangel, Antonio
影响因子：
2.8
作者：
Field, Matt;Powell, Hannah
通讯作者：
Powell, Hannah
影响因子：
25
作者：
Kable, Joseph W.;Glimcher, Paul W.
通讯作者：
Glimcher, Paul W.
影响因子：
6
作者：
Carter, BL;Tiffany, ST
通讯作者：
Tiffany, ST
DOI：
10.1111/j.1360-0443.2008.02434.x
发表时间：
2009-02
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Cyders MA;Flory K;Rainer S;Smith GT
通讯作者：
Smith GT