Association of exposure to manganese and fine motor skills in welders - Results from the WELDOX II study.
Association of exposure to manganese and fine motor skills in welders - Results from the WELDOX II study.
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DOI：
10.1016/j.neuro.2020.12.003
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发表时间：
2021-01
期刊：
影响因子：
3.4
通讯作者：
Behrens T
中科院分区：
文献类型：
--
作者：
Lotz A;Pesch B;Casjens S;Lehnert M;Zschiesche W;Taeger D;Yeh CL;Weiss T;Schmidt-Wilcke T;Quetscher C;Gabriel S;Zella MAS;Woitalla D;Dydak U;van Thriel C;Brüning T;Behrens T
本研究的目的是评估暴露于锰（Mn）对精细运动功能的影响。作为对照，共有48名焊工和30名未接触辐射的工人完成了问卷调查，接受了血液检查和电机测试。用个人采样器测量了焊工对可吸入锰的位移暴露。所有受试者均采用t1加权磁共振成像评估脑内Mn的积累。在运动障碍协会赞助的帕金森病统一评定量表第三部分修订中，焊工显示出正常的运动功能。此外，焊工在稳定性测试中表现出色，表现出比对照组更好的结果。然而，在电机测试中，焊工的速度略慢于控制组。精细运动测试结果与作为量化脑内Mn沉积的mri生物标志物的苍白球和黑质弛豫率R1之间没有关联。
The aim of this study was to evaluate the effect of exposure to manganese (Mn) on fine motor functions. A total of 48 welders and 30 unexposed workers as controls completed questionnaires, underwent blood examinations, and a motor test battery. The shift exposure of welders to respirable Mn was measured with personal samplers. For all subjects accumulations of Mn in the brain were assessed with T1-weighted magnetic resonance imaging. Welders showed normal motor functions on the Movement Disorder Society-Sponsored Revision of the Unified Parkinson Disease Rating Scale part III. Furthermore welders performed excellent on a steadiness test, showing better results than controls. However, welders were slightly slower than controls in motor tests. There was no association between fine motor test results and the relaxation rates R1 in globus pallidus and substantia nigra as MRI-based biomarkers to quantify Mn deposition in the brain.
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影响因子：
3.4
作者：
Bowler RM;Yeh CL;Adams SW;Ward EJ;Ma RE;Dharmadhikari S;Snyder SA;Zauber SE;Wright CW;Dydak U
通讯作者：
Dydak U
影响因子：
3.4
作者：
Casjens S;Dydak U;Dharmadhikari S;Lotz A;Lehnert M;Quetscher C;Stewig C;Glaubitz B;Schmidt-Wilcke T;Edmondson D;Yeh CL;Weiss T;Thriel CV;Herrmann L;Muhlack S;Woitalla D;Aschner M;Brüning T;Pesch B
通讯作者：
Pesch B
与低水平锰暴露有关的神经结局，在无症状焊接学员中。
DOI：
10.5271/sjweh.3466
发表时间：
2015-01
期刊：
Scandinavian journal of work, environment & health
影响因子：
--
作者：
Baker MG;Criswell SR;Racette BA;Simpson CD;Sheppard L;Checkoway H;Seixas NS
通讯作者：
Seixas NS
影响因子：
3.4
作者：
Chang, Yongmin;Kim, Yangho;Jeong, Kyoung Sook
通讯作者：
Jeong, Kyoung Sook
影响因子：
5.7
作者：
Keezer, Mark R.;Wolfson, Christina;Postuma, Ronald B.
通讯作者：
Postuma, Ronald B.