The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.
The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study.
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DOI：
10.1007/s00127-023-02513-0
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发表时间：
2023-10
影响因子：
4.4
通讯作者：
Fisher, Helen L.
中科院分区：
文献类型：
--
作者：
Sideli, Lucia;Aas, Monica;Quattrone, Diego;La Barbera, Daniele;La Cascia, Caterina;Ferraro, Laura;Alameda, Luis;Velthorst, Eva;Trotta, Giulia;Tripoli, Giada;Schimmenti, Adriano;Fontana, Andrea;Gayer-Anderson, Charlotte;Stilo, Simona;Seminerio, Fabio;Sartorio, Crocettarachele;Marrazzo, Giovanna;Lasalvia, Antonio;Tosato, Sarah;Tarricone, Ilaria;Berardi, Domenico;D'Andrea, Giuseppe;Arango, Celso;Arrojo, Manuel;Bernardo, Miguel;Bobes, Julio;Sanjuan, Julio;Santos, Jose Luis;Menezes, Paulo Rossi;Del-Ben, Cristina Marta;Jongsma, Hannah E.;Jones, Peter B.;Kirkbride, James B.;Llorca, Pierre-Michel;Tortell, Andrea;Pignon, Baptiste;de Haan, Lieuwe;Selten, Jean-Paul;Van Os, Jim;Rutten, Bart P.;Bentall, Richard;Di Fort, Marta;Murray, Robin M.;Morgan, Craig;Fisher, Helen L.
关键词：
本研究调查了精神病患者和社区对照儿童期虐待和认知之间的关联是否部分归因于精神病的遗传易感性。对来自EU-GEI研究的首发精神病患者（N = 755）和未受影响的对照组（N = 1219）进行了儿童期虐待、智商（IQ）、精神病家族史（FH）和精神分裂症多基因风险评分（SZ-PRS）评估。控制FH和SZ-PRS没有减弱儿童虐待和智商之间的关联的情况下或控制。研究结果表明，这些遗传倾向的表达不能解释儿童时期受虐待的成年人认知水平较低的原因。在线版本包含补充材料，可通过10.1007/s 00127 -023-02513-0获得。
This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood. The online version contains supplementary material available at 10.1007/s00127-023-02513-0.
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影响因子：
6.8
作者：
Quattrone D;Reininghaus U;Richards AL;Tripoli G;Ferraro L;Quattrone A;Marino P;Rodriguez V;Spinazzola E;Gayer-Anderson C;Jongsma HE;Jones PB;La Cascia C;La Barbera D;Tarricone I;Bonora E;Tosato S;Lasalvia A;Szöke A;Arango C;Bernardo M;Bobes J;Del Ben CM;Menezes PR;Llorca PM;Santos JL;Sanjuán J;Arrojo M;Tortelli A;Velthorst E;Berendsen S;de Haan L;Rutten BPF;Lynskey MT;Freeman TP;Kirkbride JB;Sham PC;O'Donovan MC;Cardno AG;Vassos E;van Os J;Morgan C;Murray RM;Lewis CM;Di Forti M;EU-GEI collaborators
通讯作者：
EU-GEI collaborators
DOI：
10.1176/appi.ajp.2016.16030333
发表时间：
2017-04-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Danese A;Moffitt TE;Arseneault L;Bleiberg BA;Dinardo PB;Gandelman SB;Houts R;Ambler A;Fisher HL;Poulton R;Caspi A
通讯作者：
Caspi A
影响因子：
11
作者：
Lencz, T.;Knowles, E.;Davies, G.;Guha, S.;Liewald, D. C.;Starr, J. M.;Djurovic, S.;Melle, I.;Sundet, K.;Christoforou, A.;Reinvang, I.;Mukherjee, S.;DeRosse, Pamela;Lundervold, A.;Steen, V. M.;John, M.;Espeseth, T.;Raikkonen, K.;Widen, E.;Palotie, A.;Eriksson, J. G.;Giegling, I.;Konte, B.;Ikeda, M.;Roussos, P.;Giakoumaki, S.;Burdick, K. E.;Payton, A.;Ollier, W.;Horan, M.;Donohoe, G.;Morris, D.;Corvin, A.;Gill, M.;Pendleton, N.;Iwata, N.;Darvasi, A.;Bitsios, P.;Rujescu, D.;Lahti, J.;Hellard, S. L.;Keller, M. C.;Andreassen, O. A.;Deary, I. J.;Glahn, D. C.;Malhotra, A. K.
通讯作者：
Malhotra, A. K.
DOI：
10.1097/00004583-199703000-00012
发表时间：
1997-03-01
影响因子：
13.3
作者：
Bernstein, DP;Ahluvalia, T;Handelsman, L
通讯作者：
Handelsman, L
影响因子：
4.4
作者：
Gayer-Anderson, Charlotte;Jongsma, Hannah E.;Morgan, Craig
通讯作者：
Morgan, Craig