Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide 2 antibody and anti-cyclic citrullinated peptide 3 antibody in rheumatoid arthritis
Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide 2 antibody and anti-cyclic citrullinated peptide 3 antibody in rheumatoid arthritis
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Meta分析：抗环瓜氨酸肽2抗体和抗环瓜氨酸肽3抗体在类风湿性关节炎中的诊断准确性
DOI：
10.1515/cclm-2013-0798
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发表时间：
2014-06
影响因子：
6.8
通讯作者：
Chen Wei-Xian
中科院分区：
文献类型：
--
作者：
Zhang Wen-Chao;Wu Han;Chen Wei-Xian
摘要本研究旨在评价抗CCP-3和抗CCP-2抗体对类风湿关节炎（RA）的诊断价值，并确定抗CCP-3抗体是否比抗CCP-2抗体更准确地识别类风湿关节炎患者。检索PubMed和CNKI数据库中以英文和中文发表的研究，这些研究检查了2006年1月至2013年7月期间抗CCP-3和抗CCP-2在诊断已知或疑似类风湿性关节炎中的应用。使用诊断准确性研究质量评估（QUADAS）工具对纳入的17项方法学质量研究进行了评价。使用随机效应方法总结了17项研究的敏感性、特异性、阳性和阴性似然比（分别为LR+和LR-）以及诊断比值比。抗CCP-3的合并敏感性、特异性、LR+、LR−和诊断比值比为0.737（95% CI，0.717-0.757）、0.933（95% CI，0.924-0.942）、11.096（95% CI，8.876-13.870）、0.274（95% CI，0.231-0.326）和42.908（95% CI，33.828-54.426）。对于抗CCP-2，值为0.719（95% CI，0.699-0.739），0.960（95%CI，0.953-0.966）、17.485（95%CI，11.960-25.562）、0.294（95%CI，0.258-0.335）和63.458（95%CI，44.214-91.078）。抗CCP-2和抗CCP-3抗体特异性高，敏感性中等，对RA的诊断有重要意义。抗CCP-3与抗CCP-2相比，诊断性能并不更好，但抗CCP-2与抗CCP-3相比具有明显的异质性，尤其是在美国患者中。
Abstract The aim of this work was to assess the diagnostic value of anti-CCP-3 and anti-CCP-2 for the diagnosis of rheumatoid arthritis (RA) and determine whether anti-CCP-3 more accurately identifies patients with rheumatoid arthritis than anti-CCP-2. PubMed and CNKI databases were searched for studies published in English and Chinese that examined the use of anti-CCP-3 and anti-CCP-2 in the diagnosis of known or suspected rheumatoid arthritis from January 2006 to July 2013. Seventeen included studies of methodological quality were rated by using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tools A random-effects method was used to summarize sensitivities, specificities, positive and negative likelihood ratio (LR+ and LR−, respectively), and diagnostic odds ratio from 17 studies. The pooled sensitivity, specificity, LR+, LR− and diagnostic odds ratio for anti-CCP-3 were 0.737 (95% CI, 0.717–0.757), 0.933 (95% CI, 0.924–0.942), 11.096 (95% CI, 8.876–13.870), 0.274 (95% CI, 0.231–0.326), and 42.908 (95% CI, 33.828–54.426), respectively. For anti-CCP-2, the values were 0.719 (95% CI, 0.699–0.739), 0.960 (95% CI, 0.953–0.966), 17.485 (95% CI, 11.960–25.562), 0.294 (95% CI, 0.258–0.335) and 63.458 (95% CI, 44.214–91.078), respectively. With high specificity and moderate sensitivity, anti-CCP-2 and anti-CCP-3 played an important role in confirming the diagnosis of RA. Anti-CCP-3 did not have better diagnostic performances than anti-CCP-2, but anti-CCP-2 had evident heterogeneity compared to anti-CCP-3, especially in American patients.
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影响因子：
4
作者：
Shidara, Kumi;Inoue, Eisuke;Yamanaka, Hisashi
通讯作者：
Yamanaka, Hisashi
影响因子：
27.4
作者：
Cruyssen, B. Vander;Nogueira, L.;De Keyser, F.
通讯作者：
De Keyser, F.
DOI：
10.1186/ar395
发表时间：
2002
期刊：
Arthritis research
影响因子：
--
作者：
van Boekel MA;Vossenaar ER;van den Hoogen FH;van Venrooij WJ
通讯作者：
van Venrooij WJ
影响因子：
9.1
作者：
M. Elrefaei;Kristie Boose;Martha McGee;T. Tarrant;F. Lin;J. Fine;J. Schmitz
通讯作者：
M. Elrefaei;Kristie Boose;Martha McGee;T. Tarrant;F. Lin;J. Fine;J. Schmitz
影响因子：
3.4
作者：
J. Rojas-Serrano;R. Burgos-Vargas;Leticia Lino Pérez;C. García García-C.-García-García-49141962;Francisco Moctezuma;J. Vázquez-Mellado
通讯作者：
J. Rojas-Serrano;R. Burgos-Vargas;Leticia Lino Pérez;C. García García-C.-García-García-49141962;Francisco Moctezuma;J. Vázquez-Mellado