Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value.
Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value.
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DOI：
10.1186/ar395
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
van Venrooij WJ
中科院分区：
文献类型：
--
作者：
van Boekel MA;Vossenaar ER;van den Hoogen FH;van Venrooij WJ
类风湿性关节炎（RA）的诊断主要基于临床症状，因此在疾病的早期阶段往往难以诊断。因此，能够作为血清学标记物的疾病特异性自身抗体将是非常有用的。大多数自身免疫性疾病的特点是针对多种自身抗原的多克隆b细胞反应。这些免疫反应通常不是针对单一疾病的。在这篇综述中，描述了与RA相关的最重要的自身抗体/自身抗原系统，并讨论了它们作为诊断和预后工具的用途，包括它们的特异性、敏感性和实际应用。我们得出结论，目前针对瓜氨酸化抗原的抗体反应对RA具有最有价值的诊断和预后潜力。
The diagnosis of rheumatoid arthritis (RA) is primarily based on clinical symptoms, so it is often difficult to diagnose RA in very early stages of the disease. A disease-specific autoantibody that could be used as a serological marker would therefore be very useful. Most autoimmune diseases are characterized by a polyclonal B-cell response targeting multiple autoantigens. These immune responses are often not specific for a single disease. In this review, the most important autoantibody/autoantigen systems associated with RA are described and their utility as a diagnostic and prognostic tool, including their specificity, sensitivity and practical application, is discussed. We conclude that, at present, the antibody response directed to citrullinated antigens has the most valuable diagnostic and prognostic potential for RA.
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