Influenza excess mortality from 1950-2000 in tropical Singapore.

Influenza excess mortality from 1950-2000 in tropical Singapore.
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DOI:
10.1371/journal.pone.0008096
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发表时间:
2009-12-01
期刊:
影响因子:
3.7
通讯作者:
Chen MI
Chen MI
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Lee VJ;Yap J;Ong JB;Chan KP;Lin RT;Chan SP;Goh KT;Leo YS;Chen MI

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与温带地区相比,热带地区已显示出不同的流感季节性模式。然而,关于各时期热带流感年度流行负担以及热带流感流行与其他地区之间的关系的信息很少。新加坡从1947年至2003年获得了每月全国死亡率和人口数据。为了确定每个月的超额死亡率,我们对1950年至2000年的每个月进行了移动平均分析。从1972年开始,就有了流感病毒监测数据。在1972年以前,信息是从连续的年度政府报告、同行评议的期刊文章和新闻报道中获得的。1957年和1968年的流感大流行导致大量死亡。此外,还有20个其他时间点具有显著的超额死亡率。在1972年以后死亡率显著偏高的12个时期中,只有一个时期(1988年)与记录的流感活动不相符。在1972年之前(不包括大流行年份)死亡率显著偏高的8个时期中,有2年(1951年和1953年)的报纸报道肺炎死亡人数增加。几乎在所有有流感暴发记录的时期都可以观察到过高的死亡率,但并不总是超过基线死亡率的95%置信限。在战后的新加坡热带地区,流感流行可能是造成大多数超额死亡率的原因,尽管并非每次流行病都导致高死亡率。因此,重要的是要有良好的流感监测系统来发现流感活动。
Tropical regions have been shown to exhibit different influenza seasonal patterns compared to their temperate counterparts. However, there is little information about the burden of annual tropical influenza epidemics across time, and the relationship between tropical influenza epidemics compared with other regions. Data on monthly national mortality and population was obtained from 1947 to 2003 in Singapore. To determine excess mortality for each month, we used a moving average analysis for each month from 1950 to 2000. From 1972, influenza viral surveillance data was available. Before 1972, information was obtained from serial annual government reports, peer-reviewed journal articles and press articles. The influenza pandemics of 1957 and 1968 resulted in substantial mortality. In addition, there were 20 other time points with significant excess mortality. Of the 12 periods with significant excess mortality post-1972, only one point (1988) did not correspond to a recorded influenza activity. For the 8 periods with significant excess mortality periods before 1972 excluding the pandemic years, 2 years (1951 and 1953) had newspaper reports of increased pneumonia deaths. Excess mortality could be observed in almost all periods with recorded influenza outbreaks but did not always exceed the 95% confidence limits of the baseline mortality rate. Influenza epidemics were the likely cause of most excess mortality periods in post-war tropical Singapore, although not every epidemic resulted in high mortality. It is therefore important to have good influenza surveillance systems in place to detect influenza activity.
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