Relations Between Acute Effects of Alcohol on Response Inhibition, Impaired Control over Alcohol Use, and Alcohol-Related Problems.
Relations Between Acute Effects of Alcohol on Response Inhibition, Impaired Control over Alcohol Use, and Alcohol-Related Problems.
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DOI：
10.1111/acer.14322
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发表时间：
2020-05
期刊：
影响因子：
--
通讯作者：
Leeman RF
中科院分区：
文献类型：
--
作者：
Corbin WR;Berey BL;Waddell JT;Leeman RF
在实验室中，酒精始终会损害反应抑制，而反应抑制的酒精损害可能会导致过量消费或醉酒风险行为的增加，这两者都有助于酒精相关问题的风险。据我们所知，没有先前的研究已经检查了反应抑制的酒精损害和对酒精的控制受损（即，无法遵守预定的饮酒限制）或现实世界中的酒精相关问题。目前的研究解决了文献中的这一差距。年轻成年社交饮酒者（N = 215，76%男性）参加了一项受试者间安慰剂对照酒精挑战研究，并在约2周后完成自我报告。多水平模型被用来检验这一假设，即酒精损害的反应抑制会间接导致酒精相关的问题，通过对酒精使用的控制受损。更大的酒精诱导的反应抑制障碍和酒精使用控制障碍都是酒精相关问题的重要预测因子。然而，更大的酒精诱导的反应抑制是不是一个显着的预测受损的控制酒精使用。据我们所知，这是第一个研究表明酒精损害的反应抑制和现实世界中的酒精相关问题之间的关系，第一个解决酒精损害的反应抑制和控制酒精使用受损之间的关系。这些结果表明，对酒精使用的控制受损可能是由于控制行为的特质能力的缺陷，而不是酒精诱导的反应抑制的缺陷。无论如何，研究结果表明，酒精损害的反应抑制和酒精控制受损都是不可忽视的干预目标。
Alcohol consistently impairs response inhibition in the laboratory, and alcohol impairment of response inhibition may lead to excess consumption or increases in intoxicated risk behavior, both of which contribute to risk for alcohol-related problems. To our knowledge, no prior studies have examined relations between alcohol impairment of response inhibition and either impaired control over alcohol (i.e., inability to adhere to predetermined drinking limits) or real-world alcohol-related problems. The current study addressed this gap in the literature. Young adult social drinkers (N = 215, 76% male) participated in a between-subjects, placebo-controlled alcohol challenge study and completed self-reports approximately 2 weeks later. Multilevel models were used to examine the hypothesis that alcohol impairment of response inhibition would indirectly lead to alcohol-related problems through impaired control over alcohol use. Greater alcohol-induced impairment of response inhibition and impaired control over alcohol use were both significant predictors of alcohol-related problems. However, greater alcohol-induced response inhibition was not a significant predictor of impaired control over alcohol use. To our knowledge, this is the first study demonstrating relationships between alcohol impairment of response inhibition and real-world alcohol-related problems and the first to address relationships between alcohol impairment of response inhibition and impaired control over alcohol use. These results suggest that impaired control over alcohol use may result from deficits in the trait ability to control behavior rather than deficits in alcohol-induced response inhibition. Regardless, results suggest that alcohol impairment of response inhibition and impaired control over alcohol are both worth-while intervention targets.
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DOI：
10.15288/jsa.2004.65.774
发表时间：
2004-11-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Carey, KB;Carey, MP;Henson, JM
通讯作者：
Henson, JM
影响因子：
3.4
作者：
Dick DM;Smith G;Olausson P;Mitchell SH;Leeman RF;O'Malley SS;Sher K
通讯作者：
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影响因子：
3.4
作者：
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通讯作者：
Krystal, John H.
DOI：
10.15288/jsas.2002.s14.118
发表时间：
2002-03-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Abbey, A
通讯作者：
Abbey, A
影响因子：
6
作者：
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通讯作者：
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