Metabolite differences in the medial prefrontal cortex in schizophrenia patients with and without persistent auditory verbal hallucinations: a (1)H MRS study.
Metabolite differences in the medial prefrontal cortex in schizophrenia patients with and without persistent auditory verbal hallucinations: a (1)H MRS study.
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有或没有持续性幻听的精神分裂症患者内侧前额叶皮层的代谢差异：一项 1H MRS 研究
DOI：
10.1038/s41398-022-01866-5
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发表时间：
2022-03-23
影响因子：
6.8
通讯作者：
Tang J
中科院分区：
文献类型：
--
作者：
Wang Q;Ren H;Li C;Li Z;Li J;Li H;Dai L;Dong M;Zhou J;He J;O'Neill J;Liao Y;He Y;Liu T;Chen X;Tang J
精神分裂症（SCZ）的研究表明，听觉言语幻觉（AVH）与额叶皮质，特别是内侧前额叶皮质（mPFC）的结构和功能异常有关。虽然与语言产生相关的异常前额叶网络连接已被广泛研究，但mPFC功能障碍（与SCZ的病理生理高度相关）与AVH之间的关系很少被研究。在这项研究中，质子磁共振波谱法测量了61例伴有持续性AVH （pAVH）的SCZ患者、53例无AVH（非AVH）的SCZ患者和59例健康对照（HC）的mPFC中代谢物水平。与非avh组（tNAA: p = 0.022, Glx: p = 0.012）和HC组（tNAA: p = 0.001, Glx: p = 0.001）相比，pAVH组n-乙酰-天冬氨酸+ n-乙酰-天冬氨酸-谷氨酸（tNAA: p = 0.001）和谷氨酸+谷氨酰胺（Glx: p = 0.001）水平显著降低。非avh和HC之间tNAA和Glx水平无差异。mPFC中tNAA和Glx水平与pAVH严重程度呈负相关（tNAA: r = - 0.24, p = 0.014; Glx: r = - 0.30, p = 0.002）。综上所述，SCZ患者的pAVH可能与mPFC中tNAA和Glx水平的降低有关，提示tNAA或Glx可能在pAVH的发病机制中起关键作用。
Studies of schizophrenia (SCZ) have associated auditory verbal hallucinations (AVH) with structural and functional abnormalities in frontal cortex, especially medial prefrontal cortex (mPFC). Although abnormal prefrontal network connectivity associated with language production has been studied extensively, the relationship between mPFC dysfunction (highly relevant to the pathophysiology of SCZ) and AVH has been rarely investigated. In this study, proton magnetic resonance spectroscopy was used to measure metabolite levels in the mPFC in 61 SCZ patients with persistent AVH (pAVH), 53 SCZ patients without AVH (non-AVH), and 59 healthy controls (HC). The pAVH group showed significantly lower levels of N-acetyl-aspartate + N-acetyl-aspartyl-glutamate (tNAA) and glutamate + glutamine (Glx), compared with the non-AVH (tNAA: p = 0.022, Glx: p = 0.012) and HC (tNAA: p = 0.001, Glx: p = 0.001) groups. No difference was found in the levels of tNAA and Glx between non-AVH and HC. The levels of tNAA and Glx in the mPFC was negatively correlated with the severity of pAVH (tNAA: r = −0.24, p = 0.014; Glx: r = −0.30, p = 0.002). In conclusion, pAVH in SCZ patients might be related to decreased levels of tNAA and Glx in the mPFC, indicating that tNAA or Glx might play a key role in the pathogenesis of pAVH.
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