Variants of contextual fear conditioning are differentially impaired in the juvenile rat by binge ethanol exposure on postnatal days 4-9.
Variants of contextual fear conditioning are differentially impaired in the juvenile rat by binge ethanol exposure on postnatal days 4-9.
复制标题
DOI：
10.1016/j.bbr.2010.04.003
复制
发表时间：
2010-10-15
影响因子：
2.7
通讯作者：
Stanton, Mark E.
中科院分区：
文献类型：
--
作者：
Murawski, Nathen J.;Stanton, Mark E.
众所周知，新生大鼠接触乙醇会部分损害海马体，但这种暴露只会导致依赖海马体的行为任务出现轻微或不一致的缺陷。这可能反映了这些任务的不同敏感性或部分海马区损伤后的残留功能。语境预暴露促进效应(CPFE)是语境条件作用的一种变体，在这种效应中，语境暴露和即时冲击连续发生。在测试期间，预先暴露的大鼠比没有预先暴露的对照组冻结得更多。CPFE对顺行性海马区损伤比标准的语境恐惧条件作用更敏感(例如，Rudy&O‘Reilly，2001，Cogn Effect Behav Neurosci，1，66-82)。我们报告说，出生后几天内，暴露于高剂量乙醇(5.25g/kg/天)的大鼠[PD]4-9在预先暴露于PD31的条件背景下时，与假插管和未受干扰的对照组相比，未能显示出CPFE。1)。与对照组相比，当在情景预暴露之后进行标准的情景条件试验而不是立即休克时，新生儿酒精对条件性冰冻的破坏程度要小得多。2)。对离散听觉提示(音调)的恐惧条件作用不受新生儿酒精暴露的影响，排除了可能的表现影响(实验。3)。这些结果表明，对于检测新生儿酒精所致的海马区损伤，CPFE是一项特别敏感的任务。混合的结果与其他任务可能反映了残留的海马体功能和/或在酒精诱导的脑损伤后使用了替代的神经行为系统或“策略”。
Neonatal ethanol exposure in the rat is known to partially damage the hippocampus, but such exposure causes only modest or inconsistent deficits on hippocampus-dependent behavioral tasks. This may reflect variable sensitivity of these tasks or residual function following partial hippocampal injury. The context preexposure facilitation effect (CPFE) is a variant of context conditioning in which context exposure and immediate shock occur on successive occasions. During testing, preexposed rats freeze more than non-preexposed controls. The CPFE is more sensitive to anterograde hippocampal injury than standard contextual fear conditioning (e.g., Rudy & O’Reilly, 2001, Cogn Affect Behav Neurosci, 1, 66–82). We report that rats exposed to a high binge dose of ethanol (5.25 g/kg/day) over Postnatal Days [PD] 4–9 failed to demonstrate the CPFE when preexposed to the conditioning context on PD31, relative to sham-intubated and undisturbed controls (Exp. 1). Neonatal alcohol disrupted conditioned freezing to a much lesser extent relative to controls when context preexposure was followed by a standard context conditioning trial rather than immediate shock (Exp. 2). Fear conditioning to a discrete auditory cue (tone) was unaffected by neonatal alcohol exposure ruling out possible performance effects (Exp. 3). These findings suggest that the CPFE is an especially sensitive task for detecting hippocampal injury produced by neonatal alcohol. Mixed results with other tasks may reflect residual hippocampal function and/or the use of alternate neurobehavioral systems or “strategies” following alcohol-induced brain damage.
登录
查看更多内容
DOI：
10.1111/j.1530-0277.1993.tb00808.x
发表时间：
1993-06-01
影响因子：
3.2
作者：
HAMRE, KM;WEST, JR
通讯作者：
WEST, JR
影响因子：
2.7
作者：
Barrientos, RM;O'Reilly, RC;Rudy, JW
通讯作者：
Rudy, JW
DOI：
10.1097/00000374-200003000-00007
发表时间：
2000-03-01
影响因子：
3.2
作者：
Girard, TA;Xing, HC;Wainwright, PE
通讯作者：
Wainwright, PE
影响因子：
2.5
作者：
DOBBING, J;SANDS, J
通讯作者：
SANDS, J
影响因子：
2.7
作者：
GOODLETT, CR;PETERSON, SD
通讯作者：
PETERSON, SD