Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques.
Aerosolized oxytocin increases cerebrospinal fluid oxytocin in rhesus macaques.
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DOI：
10.1016/j.psyneuen.2014.02.011
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发表时间：
2014-07
影响因子：
3.7
通讯作者：
Parr, Lisa A.
中科院分区：
文献类型：
--
作者：
Modi, Meera E.;Connor-Stroud, Fawn;Landgraf, Rainer;Young, Larry J.;Parr, Lisa A.
鼻内（IN）给药是一种广泛使用的方法，用于检查催产素（OT）对健康受试者和精神病人群的社会行为和认知的影响。 IN-OT 在人类中可以增强信任、情绪感知和移情行为，并且正在研究作为一种潜在的药物疗法，以增强各种神经精神疾病（包括自闭症谱系障碍（ASD））的社会功能。非人类灵长类动物 (NHP) 是了解 OT 对社会认知的影响、其神经机制以及开发 IN-OT 作为治疗人类社会缺陷的药物疗法的重要模型。然而，非人类灵长类动物，甚至一些人类群体，例如非常年幼的婴儿和儿童，无法轻易遵循大多数人类 IN-OT 研究中使用的详细自我给药方案。因此，我们评估了几种 OT 给药途径在提高恒河猴中枢 OT 浓度方面的功效。首先，我们检查了 IN 和静脉 (IV) OT 给药途径对血浆和腰椎 CSF 中 OT 和加压素 (AVP) 浓度的影响。其次，我们在采用雾化 (AE) OT 给药途径后的猴子身上检查了这些相同的措施。所有三种给药途径均显着增加血浆 OT 浓度，但只有 AE-OT 途径显着增加 CSF OT 浓度。没有任何途径影响血浆或脑脊液中 AVP 的浓度。这项研究证实，AE 途径是增加猴子中枢 OT 浓度的最有效方法，并且也可能是替代 IN 的有效途径，用于对某些人群进行 OT 治疗。
Intranasal (IN) administration is a widely used method for examining the effect of oxytocin (OT) on social behavior and cognition in healthy subjects and psychiatric populations. IN-OT in humans enhances trust, emotional perception, and empathetic behavior and is under investigation as a potential pharmacotherapy to enhance social functioning in a variety of neuropsychiatric disorders, including autism spectrum disorders (ASD). Nonhuman primates (NHP) are an important model for understanding the effect of OT on social cognition, its neural mechanisms, and the development of IN-OT as a pharmacotherapy for treating social deficits in humans. However, nonhuman primates and even some human populations, such as very young infants and children, cannot easily follow the detailed self-administration protocol used in the majority of human IN-OT studies. Therefore, we evaluated the efficacy of several OT-administration routes for elevating central OT concentrations in rhesus macaques. First, we examined the effect of IN and intravenous (IV) routes of OT administration on concentrations of OT and vasopressin (AVP) in plasma and lumbar CSF. Second, we examined these same measures in monkeys after an aerosolized (AE) OT delivery route. All three administration routes significantly increased plasma OT concentrations, but only the AE-OT route significantly increased concentrations of CSF OT. No route affected concentrations of AVP in plasma or CSF. This study confirms that the AE route is the most effective method for increasing central OT concentrations in monkeys, and may also be an effective route, alternative to IN, for administering OT to some human populations.
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影响因子：
6.2
作者：
Anagnostou E;Soorya L;Chaplin W;Bartz J;Halpern D;Wasserman S;Wang AT;Pepa L;Tanel N;Kushki A;Hollander E
通讯作者：
Hollander E
影响因子：
3.5
作者：
Churchland, Patricia S.;Winkielman, Piotr
通讯作者：
Winkielman, Piotr
影响因子：
3.8
作者：
Dhuria, Shyeilla V.;Hanson, Leah R.;Frey, William H., II
通讯作者：
Frey, William H., II
影响因子：
10.6
作者：
Guastella, Adam J.;Einfeld, Stewart L.;Hickie, Ian B.
通讯作者：
Hickie, Ian B.
影响因子：
64.8
作者：
Kosfeld, M;Heinrichs, M;Fehr, E
通讯作者：
Fehr, E