Imaging Cerebral Microhemorrhages in Military Service Members with Chronic Traumatic Brain Injury.
Imaging Cerebral Microhemorrhages in Military Service Members with Chronic Traumatic Brain Injury.
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在慢性创伤性脑损伤的兵役成员中成像脑微诊。
DOI：
10.1148/radiol.2015150160
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发表时间：
2016-02
期刊：
影响因子：
19.7
通讯作者：
Riedy G
中科院分区：
文献类型：
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作者：
Liu W;Soderlund K;Senseney JS;Joy D;Yeh PH;Ollinger J;Sham EB;Liu T;Wang Y;Oakes TR;Riedy G
目的：应用磁共振成像（MR）技术检测慢性颅脑损伤军人的脑微血管病变。通过使用定量易感性绘图，在一个患者子集中监测微血管造影的纵向演变。这项研究得到了沃尔特里德国家军事医学中心机构审查委员会的批准，并符合HIPAA指南。所有参与者均接受二维常规梯度回波MR成像和三维血流补偿多回波梯度回波MR成像（处理以生成磁敏感加权图像和定量磁敏感图），一部分患者接受随访成像。显微镜检查由两名放射科医师独立鉴定。通过配对t检验比较基线和随访影像学检查之间的微出血数量、大小和磁化率（来自定量磁化率图）。在603例患者中，43例患者的脑微血管造影被确定，6例因伪影而被排除进一步分析。77%（451/585）的微血管在磁共振加权成像上比梯度回波成像上有更明显的外观。37例患者中有13例接受了随访影像学检查。在这些患者中，与基线相比，在定量易感性图上，随访成像时识别出的微血管数量较少（平均值±标准差，9.8微血管± 12.8 vs 13.7微血管± 16.6; P = 0.019）。定量磁化率映射衍生的微生物量的定量测量也随时间推移而下降：总体积为-0.85 mm 3/天± 1.59（P = 0.039），平均磁化率为-0.10 ppm/天± 0.14（P = 0.016）。微血管造影的数量和定量敏感性映射衍生的微血管造影的定量测量都随着时间的推移而减少，这表明含铁血黄素产品在慢性阶段经历了持续的、微妙的演变。
To detect cerebral microhemorrhages in military service members with chronic traumatic brain injury by using susceptibility-weighted magnetic resonance (MR) imaging. The longitudinal evolution of microhemorrhages was monitored in a subset of patients by using quantitative susceptibility mapping. The study was approved by the Walter Reed National Military Medical Center institutional review board and is compliant with HIPAA guidelines. All participants underwent two-dimensional conventional gradient-recalled-echo MR imaging and three-dimensional flow-compensated multi-echo gradient-recalled-echo MR imaging (processed to generate susceptibility-weighted images and quantitative susceptibility maps), and a subset of patients underwent follow-up imaging. Microhemorrhages were identified by two radiologists independently. Comparisons of microhemorrhage number, size, and magnetic susceptibility derived from quantitative susceptibility maps between baseline and follow-up imaging examinations were performed by using the paired t test. Among the 603 patients, cerebral microhemorrhages were identified in 43 patients, with six excluded for further analysis owing to artifacts. Seventy-seven percent (451 of 585) of the microhemorrhages on susceptibility-weighted images had a more conspicuous appearance than on gradient-recalled-echo images. Thirteen of the 37 patients underwent follow-up imaging examinations. In these patients, a smaller number of microhemorrhages were identified at follow-up imaging compared with baseline on quantitative susceptibility maps (mean ± standard deviation, 9.8 microhemorrhages ± 12.8 vs 13.7 microhemorrhages ± 16.6; P = .019). Quantitative susceptibility mapping–derived quantitative measures of microhemorrhages also decreased over time: −0.85 mm3 per day ± 1.59 for total volume (P = .039) and −0.10 parts per billion per day ± 0.14 for mean magnetic susceptibility (P = .016). The number of microhemorrhages and quantitative susceptibility mapping–derived quantitative measures of microhemorrhages all decreased over time, suggesting that hemosiderin products undergo continued, subtle evolution in the chronic stage.
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影响因子：
4.4
作者：
Haacke, E. M.;Tang, J.;Neelavalli, J.;Cheng, Y. C. N.
通讯作者：
Cheng, Y. C. N.
影响因子：
3.3
作者：
Liu, Tian;Liu, Jing;Wang, Yi
通讯作者：
Wang, Yi
影响因子：
5.7
作者：
Schweser, Ferdinand;Sommer, Karsten;Reichenbach, Juergen Rainer
通讯作者：
Reichenbach, Juergen Rainer
影响因子：
48
作者：
Greenberg, Steven M.;Vernooij, Meike W.;Cordonnier, Charlotte;Viswanathan, Anand;Salman, Rustorn Al-Shahi;Warach, Steven;Launer, Lenore J.;Van Buchem, Mark A.;Breteler, Monique M. B.
通讯作者：
Breteler, Monique M. B.
DOI：
10.3174/ajnr.a2022
发表时间：
2010-08
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Wu Z;Li S;Lei J;An D;Haacke EM
通讯作者：
Haacke EM