Molecularly imprinted materials for glycan recognition and processing.
Molecularly imprinted materials for glycan recognition and processing.
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DOI：
10.1039/d2tb00164k
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发表时间：
2022-09-15
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影响因子：
--
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中科院分区：
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--
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碳水化合物是地球上最丰富的有机分子，糖基化是蛋白质最常见的翻译后修饰。聚糖参与多种生物过程，包括细胞粘附、细菌和病毒感染、炎症和癌症发展。糖苷类化合物是最早的印迹分子之一，在共价分子印迹技术的发展中发挥了重要作用。这一观点说明了最近开发的分子印迹材料的聚糖结合和处理。新型的印迹技术和后修饰导致了合成聚糖结合材料的发展，这些材料能够与天然凝集素在亲和力和人工糖苷酶中竞争复杂聚糖的选择性水解。预计这些材料将显著推进糖化学，糖生物学和相关领域，如生物质转化。分子印迹材料特别适合于聚糖识别。生物竞争结合和选择性水解聚糖是通过创新的印迹技术和印迹位点的后修饰实现的。
Carbohydrates are the most abundant organic molecules on Earth and glycosylation is the most common posttranslational modification of proteins. Glycans are involved in a plethora of biological processes including cell adhesion, bacterial and viral infection, inflammation, and cancer development. Coincidently, glycosides were some of the earliest molecules imprinted and have been instrumental in the development of covalent molecular imprinting technology. This perspective illustrates recently developed molecularly imprinted materials for glycan binding and processing. Novel imprinting techniques and postmodification led to development of synthetic glycan-binding materials capable of competing with natural lectins in affinity and artificial glycosidases for selective hydrolysis of complex glycans. These materials are expected to significantly advance glycochemistry, glycobiology, and related areas such as biomass conversion. Molecularly imprinted materials are uniquely suited for glycan recognition. Biologically competitive binding and selective hydrolysis of glycans are achieved through innovation in imprinting techniques and postmodification of the imprinted sites.
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