Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging.
Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging.
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DOI：
10.1016/j.bioactmat.2023.09.015
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发表时间：
2024-02
影响因子：
18.9
通讯作者：
中科院分区：
文献类型：
--
作者：
铁凋亡提供了一种克服癌症对常规癌症治疗方案的治疗抗性的新方法。它作为癌症治疗的有效用途需要一种精确的靶向方法，这可以通过使用纳米颗粒和纳米医学来促进，并且它们用于增强铁凋亡确实是一个不断增长的研究领域。虽然已经发表了一些关于铁依赖性机制和铁凋亡癌症治疗诱导剂的综述论文，其中部分涵盖了铁凋亡纳米颗粒，但需要对磁性纳米颗粒的设计进行全面综述，这些磁性纳米颗粒通常可以提供铁离子以促进铁凋亡，同时实现靶向铁凋亡癌症纳米医学。此外，磁性纳米颗粒可以局部诱导铁凋亡和诊断磁共振成像（MRI）的组合铁凋亡。使用远程可控的磁性纳米载体可以提供高效的局部图像引导的铁凋亡癌症纳米医学。在这里，最近的发展磁性可操纵的纳米载体的铁凋亡癌症纳米医学与医学成像进行了总结。这篇综述还强调了目前最先进的图像引导的铁凋亡癌症纳米医学的优势。最后，图像引导的组合铁凋亡癌症治疗与传统的基于铁凋亡的治疗，使协同肿瘤治疗的临床翻译进行了讨论。综述了近年来磁性纳米粒子在铁凋亡肿瘤纳米医学中的应用。综述了图像引导的铁凋亡肿瘤纳米医学的优势。磁性纳米粒子的合理设计和制造，以提高局部铁凋亡的诱导。为图像引导的铁凋亡癌症纳米医学在临床应用中提供了挑战和机遇。
Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as a cancer therapy requires a precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, and their use to enhance ferroptosis is indeed a growing area of research. While a few review papers have been published on iron-dependent mechanism and inducers of ferroptosis cancer therapy that partly covers ferroptosis nanoparticles, there is a need for a comprehensive review focusing on the design of magnetic nanoparticles that can typically supply iron ions to promote ferroptosis and simultaneously enable targeted ferroptosis cancer nanomedicine. Furthermore, magnetic nanoparticles can locally induce ferroptosis and combinational ferroptosis with diagnostic magnetic resonance imaging (MRI). The use of remotely controllable magnetic nanocarriers can offer highly effective localized image-guided ferroptosis cancer nanomedicine. Here, recent developments in magnetically manipulable nanocarriers for ferroptosis cancer nanomedicine with medical imaging are summarized. This review also highlights the advantages of current state-of-the-art image-guided ferroptosis cancer nanomedicine. Finally, image guided combinational ferroptosis cancer therapy with conventional apoptosis-based therapy that enables synergistic tumor therapy is discussed for clinical translations. Recent advances in the use of magnetic nanoparticles for ferroptosis cancer nanomedicine are summarized. The advantages of image-guided ferroptosis cancer nanomedicine are overviewed. The rational design and fabrication of magnetic nanoparticles to enhance local ferroptosis induction are described. Challenges and opportunities for image-guided ferroptosis cancer nanomedicine in clinical applications are provided.
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影响因子：
19
作者：
Bae, Gunhyu;Jeon, Yoo Sang;Kang, Heemin
通讯作者：
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Pichler, Martin