Can Horton hear the whos? The importance of scale in mosquito-borne disease.
Can Horton hear the whos? The importance of scale in mosquito-borne disease.
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DOI：
10.1603/me11168
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发表时间：
2014-03
影响因子：
2.1
通讯作者：
Tabachnick WJ
中科院分区：
文献类型：
--
作者：
Lord CC;Alto BW;Anderson SL;Connelly CR;Day JF;Richards SL;Smartt CT;Tabachnick WJ
病媒传播病原体的流行病学是由生物组织不同尺度的机制和相互作用决定的，从个体水平的细胞过程到物种之间以及与环境的群落相互作用。然而，大多数研究都集中在一个尺度或水平上，尺度之间或尺度内水平之间的整合很少。了解水平之间的相互作用以及它们如何影响我们对病媒传播病原体的看法至关重要。在这里，两个生物尺度（病原体传播和蚊子死亡率）的例子来说明一些规模的问题，并探讨如何在不同的水平上的过程可能会相互作用，以影响蚊媒病原体传播周期。生存、媒介能力和其他性状的个体差异影响种群丰度、传播潜力和群落结构。群落结构影响个体之间的相互作用，如竞争和捕食，从而影响个体水平的动态和传播潜力。建模是评估尺度之间的相互作用以及不同层次的过程如何影响传输动态的宝贵工具。我们扩展了现有的模型来说明所需的研究类型，表明获得或感染所需的病毒剂量的个体水平变化可以影响感染性载体的数量。至关重要的是，了解生物规模和生物组织水平内部和之间的相互作用，以更好地了解病原体传播，最终目标是改善对病媒传播病原体的控制。
The epidemiology of vector-borne pathogens is determined by mechanisms and interactions at different scales of biological organization, from individual-level cellular processes to community interactions between species and with the environment. Most research, however, focuses on one scale or level with little integration between scales or levels within scales. Understanding the interactions between levels and how they influence our perception of vector-borne pathogens is critical. Here two examples of biological scales (pathogen transmission and mosquito mortality) are presented to illustrate some of the issues of scale and to explore how processes on different levels may interact to influence mosquito-borne pathogen transmission cycles. Individual variation in survival, vector competence, and other traits affect population abundance, transmission potential, and community structure. Community structure affects interactions between individuals such as competition and predation, and thus influences the individual-level dynamics and transmission potential. Modeling is a valuable tool to assess interactions between scales and how processes at different levels can affect transmission dynamics. We expand an existing model to illustrate the types of studies needed, showing that individual-level variation in viral dose acquired or needed for infection can influence the number of infectious vectors. It is critical that interactions within and among biological scales and levels of biological organization are understood for greater understanding of pathogen transmission with the ultimate goal of improving control of vector-borne pathogens.
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DOI：
10.1126/science.1193162
发表时间：
2010-10-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bartholomay LC;Waterhouse RM;Mayhew GF;Campbell CL;Michel K;Zou Z;Ramirez JL;Das S;Alvarez K;Arensburger P;Bryant B;Chapman SB;Dong Y;Erickson SM;Karunaratne SH;Kokoza V;Kodira CD;Pignatelli P;Shin SW;Vanlandingham DL;Atkinson PW;Birren B;Christophides GK;Clem RJ;Hemingway J;Higgs S;Megy K;Ranson H;Zdobnov EM;Raikhel AS;Christensen BM;Dimopoulos G;Muskavitch MA
通讯作者：
Muskavitch MA
DOI：
10.1098/rspb.2007.1497
发表时间：
2008-02-22
影响因子：
4.7
作者：
Alto, Barry W.;Lounibos, L. Philip;Reiskind, Michael H.
通讯作者：
Reiskind, Michael H.
影响因子：
4.8
作者：
Alto, BW;Lounibos, LP;Juliano, SA
通讯作者：
Juliano, SA
影响因子：
2.2
作者：
Barrera, R
通讯作者：
Barrera, R
DOI：
10.1098/rspb.2002.2181
发表时间：
2002-12-22
影响因子：
4.7
作者：
Amarasekare, P
通讯作者：
Amarasekare, P