Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens.
Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens.
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DOI：
10.1126/science.1193162
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发表时间：
2010-10-01
期刊：
影响因子：
--
通讯作者：
Muskavitch MA
中科院分区：
文献类型：
--
作者：
Bartholomay LC;Waterhouse RM;Mayhew GF;Campbell CL;Michel K;Zou Z;Ramirez JL;Das S;Alvarez K;Arensburger P;Bryant B;Chapman SB;Dong Y;Erickson SM;Karunaratne SH;Kokoza V;Kodira CD;Pignatelli P;Shin SW;Vanlandingham DL;Atkinson PW;Birren B;Christophides GK;Clem RJ;Hemingway J;Higgs S;Megy K;Ranson H;Zdobnov EM;Raikhel AS;Christensen BM;Dimopoulos G;Muskavitch MA
致倦库蚊作为西尼罗河病毒（WNV）、班氏丝虫（Wuchereria bancrofti）和禽疟疾寄生虫的主要媒介，对人类和兽医健康构成重大威胁。比较染色体组学揭示了一个扩展的典型C。与埃及伊蚊和冈比亚按蚊免疫基因库的比较。C. quinquefasciatus对WNV、W. bancrofti和非本地细菌促进了对25种媒介-病原体相互作用的前所未有的荟萃分析，涉及虫媒病毒、蠕虫、细菌和疟疾寄生虫，揭示了三种蚊子属对这些病原体类型的共同和不同反应。我们的研究结果提供了支持的假设，蚊子传播的病原体已经进化到逃避先天性免疫反应，在三个媒介蚊子物种的主要医疗重要性。
The mosquito Culex quinquefasciatus poses a significant threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.
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