High and Heterogeneous Prevalence of Asymptomatic and Sub-microscopic Malaria Infections on Islands in Lake Victoria, Kenya.
High and Heterogeneous Prevalence of Asymptomatic and Sub-microscopic Malaria Infections on Islands in Lake Victoria, Kenya.
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肯尼亚维多利亚湖的岛屿上无症状和亚显微镜疟疾感染的高和异质流行。
DOI：
10.1038/srep36958
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发表时间：
2016-11-14
影响因子：
4.6
通讯作者：
Kaneko A
中科院分区：
文献类型：
--
作者：
Idris ZM;Chan CW;Kongere J;Gitaka J;Logedi J;Omar A;Obonyo C;Machini BK;Isozumi R;Teramoto I;Kimura M;Kaneko A
肯尼亚正在加强其控制疟疾的国家努力，以实现消除疟疾的目标。详细描述肯尼亚疟疾流行地区人口的疟疾感染情况是一项至关重要的优先事项，特别是对于规划和评估未来消除疟疾战略而言。本研究旨在调查肯尼亚维多利亚湖岛屿疟疾感染的分布和程度，以帮助设计消除疟疾的新干预措施。2012年1月至2014年8月期间，在维多利亚湖的四个岛屿（Mfangano、Takawiri、Kibuogi和Ngodhe）和沿海大陆（Ungoye）进行了五次横断面调查。疟疾流行率在不同环境中差别很大：Ungoye最高，其次是Mfangano大岛，其余三个小岛屿最低。3867例疟疾感染者中，无症状感染者占91.8%，亚显微镜感染者占50.3%，其中无症状感染者占94%。我们观察到亚显微感染和无症状寄生虫携带比例的地理差异和年龄依赖性。我们的研究结果突出了岛屿和维多利亚湖沿海地区疟疾流行的地方异质性，并为将大规模药物给药作为消除岛屿疟疾的一揽子干预措施的组成部分提供了支持。
Kenya is intensifying its national efforts in malaria control to achieve malaria elimination. Detailed characterization of malaria infection among populations living in the areas where the disease is endemic in Kenya is a crucial priority, especially for planning and evaluating future malaria elimination strategy. This study aimed to investigate the distribution and extent of malaria infection on islands in Lake Victoria of Kenya to aid in designing new interventions for malaria elimination. Five cross-sectional surveys were conducted between January 2012 and August 2014 on four islands (Mfangano, Takawiri, Kibuogi and Ngodhe) in Lake Victoria and a coastal mainland (Ungoye). Malaria prevalence varied significantly among settings: highest in Ungoye, followed by the large island of Mfangano and lowest in the three remaining small islands. Of the 3867 malaria infections detected by PCR, 91.8% were asymptomatic, 50.3% were sub-microscopic, of which 94% were also asymptomatic. We observed geographical differences and age dependency in both proportion of sub-microscopic infections and asymptomatic parasite carriage. Our findings highlighted the local heterogeneity in malaria prevalence on islands and a coastal area in Lake Victoria, and provided support for the inclusion of mass drug administration as a component of the intervention package to eliminate malaria on islands.
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DOI：
10.1111/j.1365-3156.2012.03001.x
发表时间：
2012-07
期刊：
Tropical medicine & international health : TM & IH
影响因子：
--
作者：
Gitonga CW;Edwards T;Karanja PN;Noor AM;Snow RW;Brooker SJ
通讯作者：
Brooker SJ
影响因子：
168.9
作者：
Kaneko, A;Taleo, G;Björkman, A
通讯作者：
Björkman, A
DOI：
10.1080/00034983.1993.11812782
发表时间：
1993-08-01
影响因子：
--
作者：
GITHEKO, AK;SERVICE, MW;JUMA, FO
通讯作者：
JUMA, FO
影响因子：
3
作者：
Jenkins, Rachel;Omollo, Raymond;Ogutu, Bernhards
通讯作者：
Ogutu, Bernhards
影响因子：
2.1
作者：
BEIER, JC;PERKINS, PV;ROBERTS, CR
通讯作者：
ROBERTS, CR