Classification of Cortical Neurons by Spike Shape and the Identification of Pyramidal Neurons.
Classification of Cortical Neurons by Spike Shape and the Identification of Pyramidal Neurons.
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DOI：
10.1093/cercor/bhab147
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发表时间：
2021-10-01
期刊：
影响因子：
--
通讯作者：
Kraskov A
中科院分区：
文献类型：
--
作者：
Lemon RN;Baker SN;Kraskov A
许多研究人员从皮层神经元的群体进行细胞外记录，现在使用尖峰形状参数，特别是尖峰持续时间，作为一种手段来分类不同的神经元亚型。由于实验方法的性质，特别是涉及非人灵长类动物，这是非常困难的，以直接验证尖峰特性属于特定类型的锥体神经元和中间神经元，如现代组织学方法所定义的。这篇评论着眼于逆行识别的锥体细胞投射到不同的目标，特别是，锥体束神经元（PTN），可以通知尖峰宽度分类的效用。尖峰持续时间可能提供线索的多样性功能的锥体细胞群，也突出了重要的差异，存在于不同物种。我们的研究表明，需要进一步的电生理和光遗传学方法来验证尖峰持续时间作为细胞分类的手段，并将其与新皮层细胞类型的良好组织学差异联系起来。
Many investigators who make extracellular recordings from populations of cortical neurons are now using spike shape parameters, and particularly spike duration, as a means of classifying different neuronal sub-types. Because of the nature of the experimental approach, particularly that involving nonhuman primates, it is very difficult to validate directly which spike characteristics belong to particular types of pyramidal neurons and interneurons, as defined by modern histological approaches. This commentary looks at the way antidromic identification of pyramidal cells projecting to different targets, and in particular, pyramidal tract neurons (PTN), can inform the utility of spike width classification. Spike duration may provide clues to a diversity of function across the pyramidal cell population, and also highlights important differences that exist across species. Our studies suggest that further electrophysiological and optogenetic approaches are needed to validate spike duration as a means of cell classification and to relate this to well-established histological differences in neocortical cell types.
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