Distinct developmental origins manifest in the specialized encoding of movement by adult neurons of the external globus pallidus.
Distinct developmental origins manifest in the specialized encoding of movement by adult neurons of the external globus pallidus.
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DOI：
10.1016/j.neuron.2015.03.007
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发表时间：
2015-04-22
期刊：
影响因子：
16.2
通讯作者：
Magill, Peter J.
中科院分区：
文献类型：
--
作者：
Dodson, Paul D.;Larvin, Joseph T.;Duffell, James M.;Garas, Farid N.;Doig, Natalie M.;Kessaris, Nicoletta;Duguid, Ian C.;Bogacz, Rafal;Butt, Simon J. B.;Magill, Peter J.
在大脑发育过程中启动的转录代码最终在成年期被实现为不同的细胞类型，在行为中发挥特殊的作用。聚焦于小鼠外苍白球（GPe），我们证明了两种gaba能GPe细胞类型对自愿行为的潜在贡献从生命早期就注定是不同的。原型GPe神经元来源于胚胎皮层下的内侧神经节隆起，表达转录因子Nkx2-1。这些神经元在清醒休息时以高速率放电，并通过不均匀的放电速率变化来编码运动，许多神经元的活动减少。相比之下，木足GPe神经元起源于外侧/尾侧神经节突起，表达转录因子FoxP2，在休息时低频率放电，并在放电强烈增加时编码运动。我们得出的结论是，发育多样性使原型神经元和树状神经元通过对GABA释放到不同基底节区靶点的不同调节，在行为中发挥不同的作用。木蒜醛和原型GPe细胞具有不同的起源和转录编码。木蒜醛神经元在运动开始时迅速而有力地增加放电率。运动由单个木蒜醛或原型神经元精确编码。两种GPe细胞类型在行为中以不同的方式影响不同的目标。发育中的大脑细胞类型规范决定了成人行为中的神经元功能。Dodson等人证明了两种gaba能苍白质投射神经元不同的胚胎起源和转录编码反映在它们不同的运动编码上。
Transcriptional codes initiated during brain development are ultimately realized in adulthood as distinct cell types performing specialized roles in behavior. Focusing on the mouse external globus pallidus (GPe), we demonstrate that the potential contributions of two GABAergic GPe cell types to voluntary action are fated from early life to be distinct. Prototypic GPe neurons derive from the medial ganglionic eminence of the embryonic subpallium and express the transcription factor Nkx2-1. These neurons fire at high rates during alert rest, and encode movements through heterogeneous firing rate changes, with many neurons decreasing their activity. In contrast, arkypallidal GPe neurons originate from lateral/caudal ganglionic eminences, express the transcription factor FoxP2, fire at low rates during rest, and encode movements with robust increases in firing. We conclude that developmental diversity positions prototypic and arkypallidal neurons to fulfil distinct roles in behavior via their disparate regulation of GABA release onto different basal ganglia targets. Arkypallidal and prototypic GPe cells have distinct origins and transcriptional codes Arkypallidal neurons rapidly and robustly increase firing rate at movement onset Movement is accurately encoded by single arkypallidal or prototypic neurons Two GPe cell types are fated to affect different targets in distinct ways in behavior Cell type specification in the developing brain informs on neuronal function in adult behavior. Dodson et al. demonstrate that distinct embryonic origins and transcriptional codes of two types of GABAergic pallidal projection neuron are reflected in their divergent encoding of movement.
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纹状体培养基神经元的功能连接组。
DOI：
10.1523/jneurosci.3833-10.2011
发表时间：
2011-01-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Chuhma N;Tanaka KF;Hen R;Rayport S
通讯作者：
Rayport S
影响因子：
64.8
作者：
Cui, Guohong;Jun, Sang Beom;Jin, Xin;Pham, Michael D.;Vogel, Steven S.;Lovinger, David M.;Costa, Rui M.
通讯作者：
Costa, Rui M.
影响因子：
5.3
作者：
Arkadir, D;Morris, G;Bergman, H
通讯作者：
Bergman, H
影响因子：
5.3
作者：
Flames, Nuria;Pla, Ramon;Marin, Oscar
通讯作者：
Marin, Oscar
影响因子：
2.9
作者：
Boraud, T;Bezard, E;Gross, C
通讯作者：
Gross, C