Expression of proteins associated with epithelial-mesenchymal transition in esophageal squamous cell carcinoma.
Expression of proteins associated with epithelial-mesenchymal transition in esophageal squamous cell carcinoma.
复制标题
食管鳞状细胞癌中上皮间质转化相关蛋白的表达。
DOI：
10.3892/ol.2017.7701
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发表时间：
2018-03
期刊：
影响因子：
2.9
通讯作者：
Chen ZN
中科院分区：
文献类型：
--
作者：
Zhang T;Li H;Zhang Y;Wang P;Bian H;Chen ZN
分化簇 147 (CD147)、垂体肿瘤转化基因 (PTTG) 和 CD44v6 是参与上皮间质转化 (EMT) 的蛋白质。为了探讨食管鳞状细胞癌（ESCC）中CD147、PTTG和CD44v6表达的预后价值，通过免疫组织化学染色评估76例食管鳞状细胞癌患者的组织芯片标本，并根据阳性区域的强度和比例进行评分。肿瘤组织中CD147、PTTG和CD44v6的表达水平高于匹配的癌旁组织。 CD147表达与淋巴结转移（P=0.025）和美国癌症联合委员会（AJCC）系统临床分级（P=0.037）呈正相关。 CD147的表达与PTTG（R=0.369；P=0.001）和CD44v6（R=0.320；P=0.005）的表达水平呈正相关。此外，Kaplan-Meier分析表明CD147、PTTG和CD44v6的阳性表达与较差的总生存时间显着相关（分别为P=0.045、P=0.014和P=0.027）。表现出 CD147-PTTG 共表达、CD147-CD44v6 共表达和 CD147-PTTG-CD44v6 三重阳性表达的患者的总生存率最差。总之，EMT 相关蛋白（包括 CD147、PTTG 和 CD44v6）的表达与 ESCC 的不良生存显着相关，这些新靶点可能作为抗癌治疗的潜在生物标志物。
Cluster of differentiation 147 (CD147), pituitary tumor transforming gene (PTTG) and CD44v6 are proteins involved in the epithelial-mesenchymal transition (EMT). To investigate the prognostic value of CD147 and PTTG, and CD44v6 expression in esophageal squamous cell carcinoma (ESCC), tissue microarray specimens from 76 patients with ESCC were evaluated by immunohistochemistry staining and scored by intensity and proportion of positive areas. Expression levels of CD147, PTTG and CD44v6 were higher in tumor tissues than in matched adjacent tissues. CD147 expression was positively associated with lymph node metastasis (P=0.025) and American Joint Committee on Cancer (AJCC) system clinical grades (P=0.037). CD147 expression was positively correlated with the expression levels of PTTG (R=0.369; P=0.001) and CD44v6 (R=0.320; P=0.005). In addition, Kaplan-Meier analysis indicated that positive expression of CD147, PTTG and CD44v6 was significantly associated with poor overall survival times (P=0.045, P=0.014 and P=0.027, respectively). Patients exhibiting CD147-PTTG co-expression, CD147-CD44v6 co-expression and CD147-PTTG-CD44v6 triple-positive expression had the poorest overall survival rates. In conclusion, the expression of EMT-associated proteins, including CD147, PTTG and CD44v6, was significantly associated with poor survival in ESCC and these novel targets may serve as potential biomarkers for anticancer therapies.
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