Parathyroid hormone treatment increases fixation of orthopedic implants with gap healing: a biomechanical and histomorphometric canine study of porous coated titanium alloy implants in cancellous bone.
Parathyroid hormone treatment increases fixation of orthopedic implants with gap healing: a biomechanical and histomorphometric canine study of porous coated titanium alloy implants in cancellous bone.
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DOI：
10.1007/s00223-010-9458-9
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发表时间：
2011-04
影响因子：
4.2
通讯作者：
Soballe, Kjeld
中科院分区：
文献类型：
--
作者：
Daugaard, Henrik;Elmengaard, Brian;Andreassen, Troels;Bechtold, Joan;Lamberg, Anders;Soballe, Kjeld
甲状旁腺激素（PTH）间歇性给药是一种骨建设肽。在关节置换术中，尽管采用了细致的手术技术，但植入物仍被间隙包围，骨整合具有挑战性。我们在实验间隙模型中检查了人PTH（1-34）对种植体固定的影响。我们将圆柱形（10 × 6 mm）多孔涂层钛合金植入物插入20只犬胫骨近端正常松质骨的同心1 mm间隙中。将动物随机分配至每天5 μg/kg PTH（1-34）治疗组。4周后，通过组织形态计量学和推出试验评价固定。骨体积在差距中显著增加。在外部间隙（500 μm）中，PTH组的骨体积分数中位数（四分位距）为27%（20-37%），对照组为10%（6-14%）。在内部间隙中，PTH组的骨体积分数为33%（26-36%），对照组为13%（11-18%）。在种植体界面，PTH组骨分数改善16%（11-20%），对照组改善10%（7-12%）（P = 0.07）。对于暴露于PTH的植入物，机械植入物固定得到改善。对于PTH，中位数（四分位距）剪切刚度显著更高（PTH 17.4 [12.7-39.7] MPa/mm和对照组8.8 [3.3-12.4] MPa/mm）（P < 0.05）。PTH的能量吸收显著增强（PTH 781 [595- 1，198.5] J/m2和对照组470 [189-596] J/m2）。观察到剪切强度增加，但不显著（PTH 3.0 [2.6-4.9]和对照组2.0 [0.9-3.0] MPa）（P = 0.08）。结果表明，PTH对周围骨中存在间隙的区域的种植体固定具有积极影响。随着进一步的研究，PTH可能在临床上用于增强这些具有挑战性的环境中的组织整合。
Parathyroid hormone (PTH) administered intermittently is a bone-building peptide. In joint replacements, implants are unavoidably surrounded by gaps despite meticulous surgical technique and osseointegration is challenging. We examined the effect of human PTH(1–34) on implant fixation in an experimental gap model. We inserted cylindrical (10 × 6 mm) porous coated titanium alloy implants in a concentric 1-mm gap in normal cancellous bone of proximal tibia in 20 canines. Animals were randomized to treatment with PTH(1–34) 5 μg/kg daily. After 4 weeks, fixation was evaluated by histomorphometry and push-out test. Bone volume was increased significantly in the gap. In the outer gap (500 μm), the bone volume fraction median (interquartile range) was 27% (20–37%) for PTH and 10% (6–14%) for control. In the inner gap, the bone volume fraction was 33% (26–36%) for PTH and 13% (11–18%) for control. At the implant interface, the bone fraction improved with 16% (11–20%) for PTH and 10% (7–12%) (P = 0.07) for control. Mechanical implant fixation was improved for implants exposed to PTH. For PTH, median (interquartile range) shear stiffness was significantly higher (PTH 17.4 [12.7–39.7] MPa/mm and control 8.8 [3.3–12.4] MPa/mm) (P < 0.05). Energy absorption was significantly enhanced for PTH (PTH 781 [595–1,198.5] J/m2 and control 470 [189–596] J/m2). Increased shear strength was observed but was not significant (PTH 3.0 [2.6–4.9] and control 2.0 [0.9–3.0] MPa) (P = 0.08). Results show that PTH has a positive effect on implant fixation in regions where gaps exist in the surrounding bone. With further studies, PTH may potentially be used clinically to enhance tissue integration in these challenging environments.
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影响因子：
5.8
作者：
Brommage, R;Hotchkiss, CE;Jerome, CP
通讯作者：
Jerome, CP
影响因子：
6.2
作者：
Dayer, Romain;Badoud, Isabelle;Ammann, Patrick
通讯作者：
Ammann, Patrick
影响因子：
6.2
作者：
Andreassen, TT;Ejersted, C;Oxlund, H
通讯作者：
Oxlund, H
DOI：
10.1563/1548-1336-34.6.298
发表时间：
2008-01-01
期刊：
The Journal of oral implantology
影响因子：
--
作者：
Corsini, Marcelo Soeiro;Faraco, Fatima N;Shibli, Jamil Awad
通讯作者：
Shibli, Jamil Awad
影响因子：
4.8
作者：
Aerssens, J;Boonen, S;Dequeker, J
通讯作者：
Dequeker, J