Sex-Dependent Effect of Platelet Nitric Oxide: Production and Platelet Reactivity in Healthy Individuals.
Sex-Dependent Effect of Platelet Nitric Oxide: Production and Platelet Reactivity in Healthy Individuals.
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DOI：
10.1016/j.jacbts.2021.10.009
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Cameron SJ
中科院分区：
文献类型：
--
作者：
Godwin MD;Aggarwal A;Hilt Z;Shah S;Gorski J;Cameron SJ
健康女性的血小板反应性高于男性。在口服硝酸盐负荷后，健康女性的血小板一氧化氮生成不成比例地比健康男性增加，女性的血小板反应性减弱，男性的血小板反应性增强。富含硝酸盐的饮食对心血管有许多好处，但其背后的机制尚不清楚。我们假设，摄入硝酸盐增加硝酸盐还原为亚硝酸盐，导致一氧化氮（NO）的产生，这可能会抑制血小板的反应性。在一项涉及健康个体的随机、双盲、安慰剂对照研究中，与男性相比，女性摄入硝酸盐增加了唾液和血浆亚硝酸盐/硝酸盐浓度，并不成比例地增强了血小板NO的产生。男性血小板NO升高的反应是血小板反应性增强，女性血小板NO显著升高的反应是血小板反应性轻度抑制。
Platelet reactivity is greater in healthy women compared with men. Following an oral nitrate load, platelet nitric oxide production increased disproportionately more in healthy women than healthy men with attenuated platelet reactivity in women and enhanced platelet reactivity in men. A nitrate-rich diet has many cardiovascular benefits, but the mechanism behind this is unclear. We hypothesized that the ingestion of nitrate augments nitrate to nitrite reduction, leading to nitric oxide (NO) production, which may suppress platelet reactivity. In a randomized, double-blinded, placebo-controlled study involving healthy individuals, ingestion of nitrate augmented saliva and plasma nitrite/nitrate concentration and enhanced platelet NO production disproportionately in women compared with men. The response of elevated platelet NO in men was increased platelet reactivity and the response of markedly elevated platelet NO in women slightly inhibited platelet reactivity.
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影响因子：
37.8
作者：
Cameron SJ;Ture SK;Mickelsen D;Chakrabarti E;Modjeski KL;McNitt S;Seaberry M;Field DJ;Le NT;Abe J;Morrell CN
通讯作者：
Morrell CN
影响因子：
10.4
作者：
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通讯作者：
Gachet, C
影响因子：
120.7
作者：
Becker, DM;Segal, J;Faraday, N
通讯作者：
Faraday, N
影响因子：
20.3
作者：
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通讯作者：
Herrington, David M.
影响因子：
5
作者：
Ferroni, Patrizia;Martini, Francesca;Guadagni, Fiorella
通讯作者：
Guadagni, Fiorella