Short-term binge drinking, marijuana, and recreational drug use trajectories in a prospective cohort of people living with HIV at the start of COVID-19 mitigation efforts in the United States.

Short-term binge drinking, marijuana, and recreational drug use trajectories in a prospective cohort of people living with HIV at the start of COVID-19 mitigation efforts in the United States.
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DOI:
10.1016/j.drugalcdep.2021.109233
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发表时间:
2022-02-01
影响因子:
4.2
通讯作者:
Wilson TE
Wilson TE
中科院分区:
医学2区
文献类型:
--
作者:
Meanley S;Choi SK;Thompson AB;Meyers JL;D'Souza G;Adimora AA;Mimiaga MJ;Kempf MC;Konkle-Parker D;Cohen MH;Teplin LA;Murchison L;Rubin LH;Rubtsova AA;Weiss DJ;Aouizerat B;Friedman MR;Plankey MW;Wilson TE

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在COVID-19大流行开始时,艾滋病专家表示,艾滋病病毒感染者(PLHIV)中精神健康诊断和药物使用的增加可能是COVID-19缓解工作的意外后果(例如,限制社会交往)。我们在一个前瞻性的PLHIV队列中评估了酗酒、大麻和娱乐性药物使用的短期轨迹。数据(N = 2121例PLHIV)包括MACS/WIHS联合队列研究(MWCCS)中两个COVID-19前(2018年10月至2019年9月)和一个COVID-19时代(2020年4月至2020年9月)时间点的物质使用行为调查回复。我们进行了基于群体的轨迹模型,用广义线性混合模型进行三角测量,以评估大流行开始时酗酒、每日大麻使用和娱乐性药物使用的变化。控制年龄和种族/民族,我们测试了性别和早期流行性抑郁症状,孤独和社会支持的轨迹是否不同。基于组的轨迹模型产生了两个轨迹组:酗酒(无vs.任何)、大麻(无/不频繁vs.每日)和娱乐性药物使用(无vs.任何)。在大流行开始时,酗酒和娱乐性药物的使用有所减少。广义线性混合模型支持这一趋势。与先前的研究一致,男性性别和大流行早期有抑郁症状与每种物质使用结果呈正相关。社会支持与娱乐性药物使用呈负相关。与假设相反,在我们的样本中,有问题的物质使用行为从大流行前到大流行后的随访中有所减少。需要进行持续监测,以评估随着大流行的持续,这种模式是否会持续下去。
At the start of the COVID-19 pandemic, HIV experts suggested that an increase in mental health diagnoses and substance use among people living with HIV (PLHIV) may be an unintended consequence of COVID-19 mitigation efforts (e.g., limiting social contact). We evaluated short-term trajectories in binge drinking, marijuana, and recreational drug use in a prospective cohort of PLHIV. Data (N = 2121 PLHIV) consist of survey responses on substance use behaviors from two pre-COVID-19 (October 2018-September 2019) and one COVID-19-era (April 2020-September 2020) timepoints within the MACS/WIHS Combined Cohort Study (MWCCS). We conducted group-based trajectory models, triangulated with generalized linear mixed models, to assess changes in binge drinking, daily marijuana use, and recreational drug use at the start of the pandemic. Controlling for age and race/ethnicity, we tested whether trajectories differed by sex and early-pandemic depressive symptoms, loneliness, and social support. Group-based trajectory models yielded two trajectory groups for binge drinking (none vs. any), marijuana (none/infrequent vs. daily), and recreational drug use (none vs. any). Binge drinking and recreational drug use decreased at the beginning of the pandemic. Generalized linear mixed model supported these trends. Consistent with prior research, male sex and having depressive symptoms early pandemic were positively associated with each substance use outcomes. Social support was inversely associated with recreational drug use. Contrary to hypotheses, problematic substance use behaviors decreased from pre-pandemic to the post-pandemic follow-up in our sample of PLHIV. Ongoing surveillance is needed to assess whether this pattern persists as the pandemic continues.
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