Executive control circuitry differentiates degree of success in weight loss following gastric-bypass surgery.
Executive control circuitry differentiates degree of success in weight loss following gastric-bypass surgery.
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执行控制电路可区分胃 - bypass手术后体重减轻的成功程度。
DOI：
10.1002/oby.20575
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发表时间：
2013-11
期刊：
影响因子：
6.9
通讯作者：
Hanlon, Colleen A.
中科院分区：
文献类型：
--
作者：
Goldman, Rachel L.;Canterberry, Melanie;Borckardt, Jeffrey J.;Madan, Alok;Byrne, T. Karl;George, Mark S.;O'Neil, Patrick M.;Hanlon, Colleen A.
虽然减肥手术的总体成功率很高，但大约20%的患者要么重新获得体重，要么从未失去预期的体重。这项研究的目的是确定胃旁路手术后，体重减轻的程度是否可以根据对食物线索的神经反应来区分。在这项功能性磁共振成像研究中，31名手术后的患者在两次平衡运行中观看食物和中性图像，在此期间，他们被指示“渴望”或“抵制”渴望。对所有参与者的食物线索的神经反应进行了评估，并在更成功（n = 24）和不太成功（n = 7）的组之间进行了进一步分析。更成功的定义是达到50%的超额减肥。总体而言，指令“渴望”引起显着的活动，在背内侧前额叶皮层（PFC），而“抵制”引起显着的活动，在背外侧PFC（DLPFC）。当被要求“渴望”时，两组之间的大脑没有差异。然而，更成功的参与者在被指示“抵抗”时，DLPFC的活动明显更多。这些研究结果表明，动员参与胃旁路手术后执行控制的神经回路的能力可能是手术后成功结局的独特组成部分。
While overall success rates of bariatric surgery are high, approximately 20% of patients either regain or never lose the expected amount of weight. The purpose of this study was to determine whether, after gastric-bypass surgery, the degree of weight loss can be differentiated based on the neural response to food cues. In this functional MRI study, 31 post-surgical patients viewed food and neutral images in two counterbalanced runs during which they were either instructed to “crave” or to “resist” craving. The neural response to food cues was assessed within and between runs for all participants, and further analyzed between more successful (n = 24) and less successful (n = 7) groups. More successful was defined by meeting 50% excess weight loss. Overall, instructions to “crave” elicited significant activity in the dorsomedial prefrontal cortex (PFC) whereas “resist” elicited significant activity in the dorsolateral PFC (DLPFC). Between groups there was no brain difference when instructed to “crave.” The more successful participants however had significantly more activity in the DLPFC when instructed to “resist.” These findings suggest that the ability to mobilize neural circuits involved in executive control post-gastric-bypass surgery may be a unique component of successful outcome post-surgery.
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影响因子：
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