Workplace based mindfulness practice and inflammation: a randomized trial.
Workplace based mindfulness practice and inflammation: a randomized trial.
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DOI：
10.1016/j.bbi.2012.10.009
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发表时间：
2013-01
影响因子：
15.1
通讯作者：
Klatt, Maryanna
中科院分区：
文献类型：
--
作者：
Malarkey, William B.;Jarjoura, David;Klatt, Maryanna
我们已经开发了一种低剂量的基于正念的干预（MBI-ld），减少了会议和正式正念练习的时间，同时在工作日进行会议。这减少了通常提到的不参与正念计划的障碍。在一项随机对照试验中，我们研究了大学教职员工（n=186），他们被发现CRP水平升高，>3.0 mg/ml，并且患有心血管疾病或有患心血管疾病的风险。这项研究旨在评估MBI-ld是否可以产生更大的降低CRP，IL-6和皮质醇比积极对照组接受生活方式教育计划时，在2个月的干预措施结束时测量。我们发现，MBI-ld显着提高了2个月的正念，并保持长达一年的时间相比，教育控制。两个月后，皮质醇、IL-6水平或自我报告的压力、抑郁和睡眠质量指标的干预措施之间没有显着变化。虽然没有统计学显著性（p= 0.08），但MBI-ld组在2个月时的CRP水平比教育对照组低1 mg/ml，这种变化可能具有临床意义。基线BMI<30（−2.67 mg/ml）的参与者比BMI> 30（− 0.18 mg/ml）的参与者对CRP的影响更大（与对照组相比）。我们的结论是，MBI-ld应该作为一种低成本的自我导向的补充策略，以减少炎症，它似乎最有前途的非肥胖受试者进行更充分的研究。
We have developed a low dose Mindfulness Based Intervention (MBI-ld) that reduces the time committed to meetings and formal mindfulness practice, while conducting the sessions during the workday. This reduced the barriers commonly mentioned for non-participation in mindfulness programs. In a controlled randomized trial we studied university faculty and staff (n=186) who were found to have an elevated CRP level, >3.0 mg/ml, and who either had, or were at risk for cardiovascular disease. This study was designed to evaluate if MBI-ld could produce a greater decrease in CRP, IL-6 and cortisol than an active control group receiving a lifestyle education program when measured at the end of the 2 month interventions. We found that MBI-ld significantly enhanced mindfulness by 2-months and it was maintained for up to a year when compared to the education control. No significant changes were noted between interventions in cortisol, IL-6 levels or self-reported measures of perceived stress, depression and sleep quality at 2-months. Although not statistically significant (p=.08), the CRP level at 2-months was one mg/ml lower in the MBI-ld group than in the education control group, a change which may have clinical significance. A larger MBI-ld effect on CRP (as compared to control) occurred among participants who had a baseline BMI<30 (−2.67 mg/ml) than for those with BMI>30 (−0.18mg/ml). We conclude that MBI-ld should be more fully investigated as a low-cost self-directed complementary strategy for decreasing inflammation, and it seems most promising for non-obese subjects.
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影响因子：
3.3
作者：
Britton, Willoughby B.;Haynes, Patricia L.;Bootzin, Richard R.
通讯作者：
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作者：
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通讯作者：
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