Long Non-Coding RNA FENDRR: Gene Structure, Expression, and Biological Relevance.
Long Non-Coding RNA FENDRR: Gene Structure, Expression, and Biological Relevance.
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长非编码 RNA FENDRR：基因结构、表达和生物学相关性。
DOI：
10.3390/genes12020177
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发表时间：
2021-01-27
期刊：
影响因子：
3.5
通讯作者：
Stankiewicz P
中科院分区：
文献类型：
--
作者：
Szafranski P;Stankiewicz P
FOXF 1邻近非编码发育调控RNA（Fendrr）在哺乳动物基因表达调控中起着重要作用。它以与相邻的Foxf 1基因相反的方向转录，与Foxf 1基因共享含有启动子的区域。在人类中，FENDRR位于染色体16q24.1上，并且受到FOXF 1远端肺特异性顺式作用增强子和反式作用FOXF 1的正调控。Fendrr已被证明是一种竞争性的内源性RNA，海绵状的microRNA和蛋白质因子，控制mRNA的稳定性，并作为染色质结构的表观遗传修饰剂周围的基因启动子和其他调控位点，靶向他们与组蛋白甲基转移酶复合物。在小鼠中，Fendrr对心脏、肺和胃肠道系统的发育至关重要;其纯合缺失导致胚胎或围产期致死。重要的是，FENDRR表达的失调也与肿瘤发生、化疗抗性、纤维化和炎性疾病有因果关系。在这里，我们审查目前的知识FENDRR的结构，表达，并参与发展和组织维护。
The FOXF1 Adjacent Noncoding Developmental Regulatory RNA (Fendrr) plays an important role in the control of gene expression in mammals. It is transcribed in the opposite direction to the neighboring Foxf1 gene with which it shares a region containing promoters. In humans, FENDRR is located on chromosome 16q24.1, and is positively regulated both by the FOXF1 distant lung-specific cis-acting enhancer and by trans-acting FOXF1. Fendrr has been shown to function as a competing endogenous RNA, sponging microRNAs and protein factors that control stability of mRNAs, and as an epigenetic modifier of chromatin structure around gene promoters and other regulatory sites, targeting them with histone methyltrasferase complexes. In mice, Fendrr is essential for development of the heart, lungs, and gastrointestinal system; its homozygous loss causes embryonic or perinatal lethality. Importantly, deregulation of FENDRR expression has been causatively linked also to tumorigenesis, resistance to chemotherapy, fibrosis, and inflammatory diseases. Here, we review the current knowledge on the FENDRR structure, expression, and involvement in development and tissue maintenance.
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