Controlled and sustained drug release performance of calcium sulfate cement porous TiO2 microsphere composites
Controlled and sustained drug release performance of calcium sulfate cement porous TiO2 microsphere composites
复制标题
硫酸钙骨水泥多孔TiO2微球复合材料的控释和缓释性能
DOI：
10.2147/ijn.s177784
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发表时间：
2018-11
影响因子：
8
通讯作者：
Yang Xianjin
中科院分区：
文献类型：
--
作者：
Luo Wei;Geng Zhen;Li Zhaoyang;Wu Shuilin;Cui Zhenduo;Zhu Shengli;Liang Yanqin;Yang Xianjin
背景硫酸钙骨水泥（CSC）是一种广泛应用于骨修复和再生的骨传导生物材料。目的在本研究中，多孔二氧化钛微球添加到CSC，以实现控制和持续的药物（庆大霉素）释放。方法采用扫描电子显微镜（SEM）、透射电子显微镜（TEM）、X射线粉末衍射（XRD）、BET比表面积分析等方法对TiO2微球和复合骨水泥的形貌、物相组成和比表面积进行分析。此外，在体外降解过程中，复合骨水泥的注射时间，抗压强度，降解行为和抗菌能力进行了检查。使用紫外分光光度计记录庆大霉素释放曲线。结果纳米二氧化钛微球具有良好的载药性能。添加TiO 2微球提高了复合水泥的可注射性和抗压强度，其最大值在TiO 2负载量为5wt.%时达到。当浸泡在模拟体液（SBF）中时，观察到掺杂有TiO2微球的复合骨水泥以稳定和持续的方式释放庆大霉素，特别是在体外降解的后期。在降解过程中，CSC掺杂TiO2微球表现出典型的类磷灰石行为。此外，抗菌分析表明，CSC掺杂TiO2微球表现出长期的抗菌活性。结论TiO2微球作为一种有效的缓释材料在骨水泥中具有良好的应用前景。
Background Calcium sulphate cement (CSC) is widely used as an osteoconductive biomaterial in bone repair and regeneration. Purpose In this study, porous TiO2 microspheres were added to CSC to achieve a controlled and sustained drug (gentamicin) release. Methods Scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), and Brunauer-Emmett-Teller (BET) surface area analysis were conducted to analyse the morphology, phase composition, and surface area of the TiO2 micro-spheres and composite cements. In addition, the injection time, compressive strength, degradation behaviour, and antibacterial ability of the composite cements were examined during in vitro degradation. Gentamicin release profile was recorded using an ultraviolet spectrophotometer. Results The results revealed the excellent drug loading ability of the TiO2 microspheres. The addition of TiO2 microspheres improved the injectability and compressive strength of the composite cements, the maximum value of which was achieved at a TiO2 loading of 5 wt.%. When immersed in simulated body fluid (SBF), the composite cements doped with TiO2 microspheres were observed to release gentamicin in a stable and sustained manner, especially in the latter stages of in vitro degradation. During degradation, CSC doped with TiO2 microspheres exhibited a typical apatite-like behaviour. Further, antibacterial analysis showed that CSC doped with TiO2 microspheres exhibited long-term antibiotic activity. Conclusion Thus, as an effective sustained-release formulation material, TiO2 microspheres show a great potential for application in bone cements.
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DOI：
10.1152/ajpcell.1994.266.3.c590
发表时间：
1994-03
期刊：
The American journal of physiology
影响因子：
--
作者：
T. Takahashi;S. Ueda;K. Takahashi;R. Scow
通讯作者：
T. Takahashi;S. Ueda;K. Takahashi;R. Scow
影响因子：
9.7
作者：
Monteiro, Nelson;Martins, Margarida;Neves, Nuno M.
通讯作者：
Neves, Nuno M.
DOI：
10.1016/j.jmbbm.2013.10.008
发表时间：
2014-01-01
影响因子：
3.9
作者：
Slane, Josh;Vivanco, Juan;Squire, Matthew
通讯作者：
Squire, Matthew
影响因子：
14
作者：
Apelt, D;Theiss, F;von Rechenberg, B
通讯作者：
von Rechenberg, B
影响因子：
5.8
作者：
Kumeria, Tushar;Mon, Htwe;Losic, Dusan
通讯作者：
Losic, Dusan