Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease.
Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease.
复制标题
冠状动脉疾病患者对精神压力的大脑皮质过度激活。
DOI：
10.1073/pnas.95.11.6454
复制
发表时间：
1998
影响因子：
11.1
通讯作者：
Goldman-Rakic,P
中科院分区：
文献类型：
--
作者：
Soufer,R;Bremner,JD;Arrighi,JA;Cohen,I;Zaret,BL;Burg,MM;Goldman-Rakic,P
冠状动脉疾病（CAD）患者的精神应激对中枢神经系统（CNS）的影响尚未探讨。本研究使用正电子发射断层扫描（PET）测量CAD和健康受试者的算术串行减法任务引起的精神应激的大脑相关性。与健康受试者相比，精神应激导致CAD患者在多个脑区过度激活，包括左顶叶皮层[角回/平行沟（39区）]、左前扣带回（32区）、右视觉关联皮层（18区）、左梭状回和小脑。这些相同的区域在CAD患者组中在精神压力与对照条件下被激活。在健康受试者组中，与计数控制相比，在精神应激期间仅在左额下回激活显著。与健康受试者相比，CAD患者的右丘脑（背外侧、后外侧）、右额上级回（32、24和10区）和右颞中回（21区）（听觉联合皮层区域）的血流也因精神应激而减少。特别值得注意的是，在精神应激期间发生无痛性心肌缺血的CAD患者亚组在左侧海马和顶下小叶（区域40）、左侧中间（区域10）和上级额回（区域8）、颞极和视觉关联皮层（区域18）中存在过度激活，并且在双侧前扣带回中观察到伴随的激活减少，右额中回、额上级回、右视觉联合皮层（18区）与无心肌缺血的CAD患者比较。这些研究结果表明，CAD患者的大脑皮质反应过度，对精神压力的不对称性过度。
The central nervous system (CNS) effects of mental stress in patients with coronary artery disease (CAD) are unexplored. The present study used positron emission tomography (PET) to measure brain correlates of mental stress induced by an arithmetic serial subtraction task in CAD and healthy subjects. Mental stress resulted in hyperactivation in CAD patients compared with healthy subjects in several brain areas including the left parietal cortex [angular gyrus/parallel sulcus (area 39)], left anterior cingulate (area 32), right visual association cortex (area 18), left fusiform gyrus, and cerebellum. These same regions were activated within the CAD patient group during mental stress versus control conditions. In the group of healthy subjects, activation was significant only in the left inferior frontal gyrus during mental stress compared with counting control. Decreases in blood flow also were produced by mental stress in CAD versus healthy subjects in right thalamus (lateral dorsal, lateral posterior), right superior frontal gyrus (areas 32, 24, and 10), and right middle temporal gyrus (area 21) (in the region of the auditory association cortex). Of particular interest, a subgroup of CAD patients that developed painless myocardial ischemia during mental stress had hyperactivation in the left hippocampus and inferior parietal lobule (area 40), left middle (area 10) and superior frontal gyrus (area 8), temporal pole, and visual association cortex (area 18), and a concomitant decrease in activation observed in the anterior cingulate bilaterally, right middle and superior frontal gyri, and right visual association cortex (area 18) compared with CAD patients without myocardial ischemia. These findings demonstrate an exaggerated cerebral cortical response and exaggerated asymmetry to mental stress in individuals with CAD.
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DOI：
10.1176/ajp.152.7.973
发表时间：
1995-07
期刊：
The American journal of psychiatry
影响因子：
--
作者：
J. Bremner;P. Randall;T. Scott;R. Bronen;J. Seibyl;S. Southwick;R. Delaney;G. McCarthy;D. Cha
通讯作者：
J. Bremner;P. Randall;T. Scott;R. Bronen;J. Seibyl;S. Southwick;R. Delaney;G. McCarthy;D. Cha
DOI：
10.1073/pnas.91.6.2008
发表时间：
1994-03-15
影响因子：
11.1
作者：
KAPUR, S;CRAIK, FIM;BROWN, GM
通讯作者：
BROWN, GM
影响因子：
2.6
作者：
Dehaene, S;Tzourio, N;Mazoyer, B
通讯作者：
Mazoyer, B
使用 18FDG 正电子发射断层扫描对正常对照和癫痫受试者的工作记忆进行研究。
DOI：
--
发表时间：
1996
期刊：
Life Science
影响因子：
--
作者：
B. Swartz;E. Halgren;F. Simpkins;M. Mandelkern
通讯作者：
M. Mandelkern
影响因子：
1.7
作者：
Kosslyn, SM;Shin, LM;Alpert, NM
通讯作者：
Alpert, NM