Air pollution alters Staphylococcus aureus and Streptococcus pneumoniae biofilms, antibiotic tolerance and colonisation.
Air pollution alters Staphylococcus aureus and Streptococcus pneumoniae biofilms, antibiotic tolerance and colonisation.
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DOI：
10.1111/1462-2920.13686
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发表时间：
2017-05
影响因子：
5.1
通讯作者：
Morrissey JA
中科院分区：
文献类型：
--
作者：
Hussey SJK;Purves J;Allcock N;Fernandes VE;Monks PS;Ketley JM;Andrew PW;Morrissey JA
空气污染是世界上最大的单一环境健康风险（世卫组织）。黑碳等颗粒物是空气污染的主要成分之一。颗粒物对人类健康的影响已得到充分证实，但对人类和自然环境中生态系统的核心生物细菌的影响却知之甚少。我们在这里首次报道，黑碳极大地改变了细菌生物膜的发展，这是细菌定植和生存的关键方面。我们的数据表明，暴露于黑碳诱导的结构，组成和功能的变化，在生物膜的两个S。肺炎链球菌和S.金黄色。重要的是，生物膜对多种抗生素和蛋白水解降解的耐受性受到显著影响。此外，我们的研究结果表明，黑碳影响体内细菌定植。在小鼠鼻咽定殖模型中，黑碳引起S。肺炎从鼻咽扩散到肺部，这是随后感染所必需的。因此，我们的研究强调了空气污染对细菌的显著影响，而这种影响在很大程度上被忽视了。因此，这些发现对空气污染对人类健康和全球细菌生态系统的影响具有重要意义。
Air pollution is the world's largest single environmental health risk (WHO). Particulate matter such as black carbon is one of the main components of air pollution. The effects of particulate matter on human health are well established however the effects on bacteria, organisms central to ecosystems in humans and in the natural environment, are poorly understood. We report here for the first time that black carbon drastically changes the development of bacterial biofilms, key aspects of bacterial colonisation and survival. Our data show that exposure to black carbon induces structural, compositional and functional changes in the biofilms of both S. pneumoniae and S. aureus. Importantly, the tolerance of the biofilms to multiple antibiotics and proteolytic degradation is significantly affected. Additionally, our results show that black carbon impacts bacterial colonisation in vivo. In a mouse nasopharyngeal colonisation model, black carbon caused S. pneumoniae to spread from the nasopharynx to the lungs, which is essential for subsequent infection. Therefore our study highlights that air pollution has a significant effect on bacteria that has been largely overlooked. Consequently these findings have important implications concerning the impact of air pollution on human health and bacterial ecosystems worldwide.
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影响因子：
5.4
作者：
Faustini, Annunziata;Stafoggia, Massimo;Forastiere, Francesco
通讯作者：
Forastiere, Francesco
影响因子：
4.2
作者：
Cattaneo, Raffaela;Rouviere, Christian;Weinbauer, Markus G.
通讯作者：
Weinbauer, Markus G.
影响因子：
3.7
作者：
Chaudhuri N;Jary H;Lea S;Khan N;Piddock KC;Dockrell DH;Donaldson K;Duffin R;Singh D;Parker LC;Sabroe I
通讯作者：
Sabroe I
影响因子：
9.4
作者：
HUANG, MB;GAY, TE;TENOVER, FC
通讯作者：
TENOVER, FC
影响因子：
8.3
作者：
Lundborg, Margot;Bouhafs, Rabea;Jarstrand, Connie
通讯作者：
Jarstrand, Connie