Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity.
Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity.
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DOI：
10.1016/j.pscychresns.2011.06.014
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发表时间：
2011-10-31
影响因子：
2.3
通讯作者：
Dickerson, Bradford C.
中科院分区：
文献类型：
--
作者：
Poulin, Stephane P.;Dautoff, Rebecca;Morris, John C.;Barrett, Lisa Feldman;Dickerson, Bradford C.
尽管关于内侧颞叶结构在阿尔茨海默病（AD）中的作用的研究很多，但杏仁核萎缩的程度和临床意义的研究相对较少。在这项研究中，我们比较了两个大样本（样本1 n=90;样本2 n=174）中非常轻度和轻度AD受试者的杏仁核萎缩水平与海马萎缩水平。使用一系列线性回归分析，我们研究了杏仁核萎缩是否与整体认知功能（临床痴呆评分总和：CDR-SB;简易精神状态检查：MMSE）和神经精神状态有关。结果表明，杏仁核萎缩是在两个样本海马萎缩。MMSE和CDR-SB与杏仁核萎缩密切相关，杏仁核萎缩预测MMSE评分以及海马萎缩，但预测CDR-SB评分不太可靠。杏仁核萎缩与异常运动行为有关，与焦虑和易怒有潜在关系。这些结果表明，杏仁核萎缩的程度与AD最早临床阶段的海马萎缩程度相当，并且与总体疾病严重程度相关。杏仁核萎缩的程度和神经精神症状之间似乎也存在特定的关系，值得进一步研究。
Despite numerous studies on the role of medial temporal lobe structures in Alzheimer's disease (AD), the magnitude and clinical significance of amygdala atrophy has been relatively sparsely investigated. In this study we compared the level of amygdala atrophy to that of the hippocampus in very mild and mild AD subjects in two large samples (Sample 1 n=90; Sample 2 n=174). Using a series of linear regression analyses, we investigated whether amygdala atrophy is related to global cognitive functioning (Clinical Dementia Rating Sum of Boxes: CDR-SB; Mini Mental State Examination: MMSE) and neuropsychiatric status. Results indicated that amygdala atrophy was comparable to hippocampal atrophy in both samples. MMSE and CDR-SB were strongly related to amygdala atrophy, with amygdala atrophy predicting MMSE scores as well as hippocampal atrophy, but predicting CDR-SB scores less robustly. Amygdala atrophy was related to aberrant motor behavior, with potential relationships to anxiety and irritability. These results suggest that the magnitude of amygdala atrophy is comparable to that of the hippocampus in the earliest clinical stages of AD, and is related to global illness severity. There also appear to be specific relationships between the level of amygdala atrophy and neuropsychiatric symptoms that deserve further investigation.
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影响因子：
2.3
作者：
Farrow, Tom F. D.;Thiyagesh, Subha N.;Woodruff, Peter W. R.
通讯作者：
Woodruff, Peter W. R.
影响因子：
9.9
作者：
Jack, CR;Petersen, RC;Kokmen, E
通讯作者：
Kokmen, E
影响因子：
10.6
作者：
Davidson, RJ
通讯作者：
Davidson, RJ
影响因子：
--
作者：
HERZOG, AG;KEMPER, TL
通讯作者：
KEMPER, TL
影响因子：
--
作者：
Kile, Shawn J.;Ellis, William G.;DeCarli, Charles
通讯作者：
DeCarli, Charles