Genes of the antioxidant system of the honey bee: annotation and phylogeny.

Genes of the antioxidant system of the honey bee: annotation and phylogeny.
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DOI:
10.1111/j.1365-2583.2006.00695.x
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发表时间:
2006-10
影响因子:
2.6
通讯作者:
Robinson GE
Robinson GE
中科院分区:
农林科学2区
文献类型:
--
作者:
Corona M;Robinson GE

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抗氧化酶具有多种重要功能,包括减少缩短寿命的氧化损伤。我们使用蜜蜂基因组序列来鉴定蜜蜂抗氧化系统的主要成分。对蜜蜂与黑腹果蝇和冈比亚按蚊的比较分析表明,尽管抗氧化系统的基本成分是保守的,但并列动物的数量存在重要的物种差异。这些包括在果蝇中硫氧还蛋白还原酶的复制和硫氧还蛋白家族的扩展;在蜜蜂中缺乏Theta、Delta和Omega GST类的扩展,在双翅目物种中没有Sigma类的扩展。蜜蜂和双翅目昆虫之间抗氧化基因家族的差异扩展可能反映了群居物种和独居物种在生活史和生态位上的显著差异。
Antioxidant enzymes perform a variety of vital functions including the reduction of life-shortening oxidative damage. We used the honey bee genome sequence to identify the major components of the honey bee antioxidant system. A comparative analysis of honey bee with Drosophila melanogaster and Anopheles gambiae shows that although the basic components of the antioxidant system are conserved, there are important species differences in the number of paralogs. These include the duplication of thioredoxin reductase and the expansion of the thioredoxin family in fly; lack of expansion of the Theta, Delta and Omega GST classes in bee and no expansion of the Sigma class in dipteran species. The differential expansion of antioxidant gene families among honey bees and dipteran species might reflect the marked differences in life history and ecological niches between social and solitary species.
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