Does the microbiota play a role in the pathogenesis of autoimmune diseases?
Does the microbiota play a role in the pathogenesis of autoimmune diseases?
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DOI：
10.1136/gutjnl-2014-308514
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发表时间：
2015-03
期刊：
影响因子：
24.5
通讯作者：
Young HA
中科院分区：
文献类型：
--
作者：
McLean MH;Dieguez D Jr;Miller LM;Young HA
人类超有机体的微生物群不仅仅是旁观者。这些微生物与我们共同进化，对正常发育和体内平衡至关重要。GI微生物群的生态失调与许多疾病易感性相关，包括肥胖、恶性肿瘤、肝病和GI病理学如IBD。很明显，在这种微生物群落和宿主免疫应答之间存在直接和间接的串扰。然而，这种微生物对疾病发病机制的影响的确切机制仍然难以捉摸，现在是一个主要的研究热点。关于微生物群在自身免疫性疾病发病机制中的作用的文献不断涌现，越来越多的证据表明微生物群的变化与其中一些疾病有关。例子包括1型糖尿病、乳糜泻和类风湿性关节炎，这些对全球发病率和死亡率有显着影响。了解微生物群在自身免疫性疾病中的作用可以为启动和驱动疾病进展的因素提供新的见解，对患者并发症的风险进行分层，并最终提供新的治疗策略。本文综述了微生物群在自身免疫性疾病中的作用。
The microbiota of the human metaorganism is not a mere bystander. These microbes have coevolved with us and are pivotal to normal development and homoeostasis. Dysbiosis of the GI microbiota is associated with many disease susceptibilities, including obesity, malignancy, liver disease and GI pathology such as IBD. It is clear that there is direct and indirect crosstalk between this microbial community and host immune response. However, the precise mechanism of this microbial influence in disease pathogenesis remains elusive and is now a major research focus. There is emerging literature on the role of the microbiota in the pathogenesis of autoimmune disease, with clear and increasing evidence that changes in the microbiota are associated with some of these diseases. Examples include type 1 diabetes, coeliac disease and rheumatoid arthritis, and these contribute significantly to global morbidity and mortality. Understanding the role of the microbiota in autoimmune diseases may offer novel insight into factors that initiate and drive disease progression, stratify patient risk for complications and ultimately deliver new therapeutic strategies. This review summarises the current status on the role of the microbiota in autoimmune diseases.
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