Reciprocating intestinal flows enhance glucose uptake in C. elegans.
Reciprocating intestinal flows enhance glucose uptake in C. elegans.
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DOI：
10.1038/s41598-022-18968-1
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发表时间：
2022-09-21
影响因子：
4.6
通讯作者：
Ishikawa, Takuji
中科院分区：
文献类型：
--
作者：
Suzuki, Yuki;Kikuchi, Kenji;Numayama-Tsuruta, Keiko;Ishikawa, Takuji
尽管其生理和病理的重要性，在肠道和肠流中的葡萄糖摄取之间的机械关系是不清楚的。在秀丽隐杆线虫的肠道中，排便运动程序（Recombination motor program，缩写为RECEPTOR）引起往复的肠流。虽然肠上皮细胞在肠道中经常被激活，但其生理功能尚不清楚。我们评估了增强的葡萄糖摄取的机械签名的蠕虫。由于机械混合和运输，葡萄糖摄取倾向于随着流速的增加而增加。然而，与卡路里摄入量相比，摄入卡路里所需的输入能量的增加是低的。研究结果表明，具有胃肠动力的动物利用由消化引起的往复式肠流来促进肠细胞的营养吸收。
Despite its physiological and pathological importance, the mechanical relationship between glucose uptake in the intestine and intestinal flows is unclear. In the intestine of the nematode Caenorhabditis elegans, the defecation motor program (DMP) causes reciprocating intestinal flows. Although the DMP is frequently activated in the intestines, its physiological function is unknown. We evaluated the mechanical signature of enhanced glucose uptake by the DMP in worms. Glucose uptake tended to increase with increasing flow velocity during the DMP because of mechanical mixing and transport. However, the increase in input energy required for the DMP was low compared with the calorie intake. The findings suggest that animals with gastrointestinal motility exploit the reciprocating intestinal flows caused by peristalsis to promote nutrient absorption by intestinal cells.
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影响因子：
1.2
作者：
Ghafouri, Shervin;McGhee, James D.
通讯作者：
McGhee, James D.
影响因子：
9.5
作者：
Gim-Krumm, Minghai;Donoso, Pablo;Troncoso, Elizabeth
通讯作者：
Troncoso, Elizabeth
影响因子：
29.4
作者：
HARRIS, MS;KENNEDY, JG
通讯作者：
KENNEDY, JG
影响因子：
4
作者：
Bender, Aaron;Woydziak, Zachary R.;Fu, Liqiang;Branden, Michael;Zhou, Zhenguo;Ackley, Brian D.;Peterson, Blake R.
通讯作者：
Peterson, Blake R.
影响因子：
6
作者：
Ishikawa T;Omori T;Kikuchi K
通讯作者：
Kikuchi K