Bacteria from diverse habitats colonize and compete in the mouse gut.
Bacteria from diverse habitats colonize and compete in the mouse gut.
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DOI：
10.1016/j.cell.2014.09.008
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发表时间：
2014-10-09
期刊：
影响因子：
64.5
通讯作者：
Gordon JI
中科院分区：
文献类型：
--
作者：
Seedorf H;Griffin NW;Ridaura VK;Reyes A;Cheng J;Rey FE;Smith MI;Simon GM;Scheffrahn RH;Woebken D;Spormann AM;Van Treuren W;Ursell LK;Pirrung M;Robbins-Pianka A;Cantarel BL;Lombard V;Henrissat B;Knight R;Gordon JI
为了研究微生物如何在哺乳动物肠道环境中建立自己，我们用来自人类，斑马鱼和白蚁肠道，人类皮肤和舌头，土壤和河口微生物垫的微生物群落定殖无菌小鼠。来自这些外来环境的细菌在小鼠肠道中定植并持续存在;它们代谢饮食和宿主碳水化合物以及胆汁酸的能力与定植成功相关。将携带这些异种微生物群的小鼠与携带天然肠道微生物群的小鼠以及无菌的“旁观者”共居，揭示了特定细菌分类群在空肠道栖息地和具有已建立群落的肠道中定植的成功。观察到了意想不到的生态演替模式;例如，即使在其他肠道群落（斑马鱼和白蚁）的细菌存在的情况下，土壤来源的细菌也占主导地位，而人类来源的细菌在小鼠来源的生物体之前定殖于无菌小鼠。这种方法概括地解决了各种有关继承的机制问题，包括微生物菌群导向疗法背景下的继承。
To study how microbes establish themselves in a mammalian gut environment, we colonized germ-free mice with microbial communities from human, zebrafish and termite guts, human skin and tongue, soil, and estuarine microbial mats. Bacteria from these foreign environments colonized and persisted in the mouse gut; their capacity to metabolize dietary and host carbohydrates, and bile acids, correlated with colonization success. Co-housing mice harboring these xenomicrobiota with one another, with mice harboring native gut microbiota, and germ-free ‘bystanders’ revealed the success of particular bacterial taxa in colonizing an empty gut habitat and guts with established communities. Unanticipated patterns of ecological succession were observed; for example, a soil-derived bacterium dominated even in the presence of bacteria from other gut communities (zebrafish and termite), and human-derived bacteria colonized germ-free mice before mouse-derived organisms. This approach generalizes to address a variety of mechanistic questions about succession, including succession in the context of microbiota-directed therapeutics.
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DOI：
10.1126/science.1241214
发表时间：
2013-09-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ridaura VK;Faith JJ;Rey FE;Cheng J;Duncan AE;Kau AL;Griffin NW;Lombard V;Henrissat B;Bain JR;Muehlbauer MJ;Ilkayeva O;Semenkovich CF;Funai K;Hayashi DK;Lyle BJ;Martini MC;Ursell LK;Clemente JC;Van Treuren W;Walters WA;Knight R;Newgard CB;Heath AC;Gordon JI
通讯作者：
Gordon JI
影响因子：
9.4
作者：
Gomez, Eric;Gustafson, Daniel R.;Patel, Robin
通讯作者：
Patel, Robin
DOI：
10.1099/ijs.0.026567-0
发表时间：
2012-01-01
影响因子：
2.8
作者：
Chen, Wen;Wang, Baojun;Liu, Shuang-Jiang
通讯作者：
Liu, Shuang-Jiang
影响因子：
29.4
作者：
Vrieze, Anne;Van Nood, Els;Nieuwdorp, Max
通讯作者：
Nieuwdorp, Max
影响因子：
56.9
作者：
Ley, Ruth E.;Hamady, Micah;Gordon, Jeffrey I.
通讯作者：
Gordon, Jeffrey I.