NOMPC, a member of the TRP channel family, localizes to the tubular body and distal cilium of Drosophila campaniform and chordotonal receptor cells.
NOMPC, a member of the TRP channel family, localizes to the tubular body and distal cilium of Drosophila campaniform and chordotonal receptor cells.
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DOI：
10.1002/cm.20493
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发表时间：
2011-01
期刊：
影响因子：
2.9
通讯作者：
Howard, Jonathon
中科院分区：
文献类型：
--
作者：
Liang, Xin;Madrid, Johnson;Saleh, Henri S.;Howard, Jonathon
机械感受是触觉、听觉和平衡感的基础。机械感受中的早期事件是响应于撞击在细胞上的机械力而打开离子通道。在这里，我们报告的抗体定位NOMPC，瞬时受体电位（TRP）离子通道家族的成员，在halteres的钟状受体的管状体和在约翰斯顿的器官，苍蝇的声音感觉器官的弦音神经元的纤毛的远端区域。由于NOMPC已被证明与机械转导过程，我们的研究表明，在这两种类型的感觉细胞的转导装置位于一个专门的微管为基础的细胞骨架是在接近覆盖表皮结构的区域。这种定位暗示了机械刺激到细胞的传递途径。此外，NOMPC的位置在两种结构不同的受体类型的共性表明一个保守的转导装置，涉及细胞内的细胞骨架和细胞外基质。© 2010 Wiley-Liss公司。
Mechanoreception underlies the senses of touch, hearing and balance. An early event in mechanoreception is the opening of ion channels in response to mechanical force impinging on the cell. Here, we report antibody localization of NOMPC, a member of the transient receptor potential (TRP) ion channel family, to the tubular body of campaniform receptors in the halteres and to the distal regions of the cilia of chordotonal neurons in Johnston's organ, the sound-sensing organ of flies. Because NOMPC has been shown to be associated with the mechanotransduction process, our studies suggest that the transduction apparatus in both types of sensory cells is located in regions where a specialized microtubule-based cytoskeleton is in close proximity to an overlying cuticular structure. This localization suggests a transmission route of the mechanical stimulus to the cell. Furthermore, the commonality of NOMPC locations in the two structurally different receptor types suggests a conserved transduction apparatus involving both the intracellular cytoskeleton and the extracellular matrix. © 2010 Wiley-Liss, Inc.
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