Research Trends, Biases, and Gaps in Phytochemicals as Insecticides: Literature Survey and Meta-Analysis.
Research Trends, Biases, and Gaps in Phytochemicals as Insecticides: Literature Survey and Meta-Analysis.
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DOI：
10.3390/plants12020318
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发表时间：
2023-01-10
期刊：
影响因子：
--
通讯作者：
Guedes RNC
中科院分区：
文献类型：
--
作者：
Collares LJ;Turchen LM;Guedes RNC
进行了76年的文献调查和荟萃分析，以了解主要植物源化合物或植物化学物质作为杀虫剂的研究的趋势、偏差和知识差距。调查发现，被认为是杀虫剂的主要植物化学物质属于以下主要化学类：萜类、萜类和羰基，所有这些化学物质都进行了测试，主要是对甲虫(鞘翅目)、毛虫(即鳞翅目幼虫)和蚊子和其他苍蝇(即双翅目)。这些研究正在以指数级的速度迅速发展，显然侧重于死亡终点估计，但它们也忽视了亚致死评估。亚洲的中国和印度，以及美洲的巴西，负责了大部分研究。大多数论文使用储粮昆虫作为实验模型，这限制了研究结果的适用性和代表性。因此，测试的主要暴露方式是熏蒸和接触，这导致这些研究中估计的致死浓度普遍存在。因此，需要对更广泛的昆虫种类进行测试，采用适当的暴露模式来识别和表征负责杀虫活动的主要分子，这是很少进行的。对这些需求的关注将绕过目前的偏见，并使人们能够认识到植物化学物质的来源和结构与其杀虫效果之间的主要联系模式。
A 76-year literature survey and meta-analyses were carried out to recognize the trends, biases, and knowledge gaps of studies focusing on major groups of compounds of botanical origin, or phytochemicals, as insecticides. The survey found that the main phytochemicals prospected as insecticides belong to the following major chemical groups: terpenoids, terpenes, and carbonyl, all of which were tested, mainly against beetles (Coleoptera), caterpillars (i.e., larvae of Lepidoptera), and mosquitoes and other flies (i.e., Diptera). These studies are burgeoning at an exponential rate, with an evident focus on mortality endpoint estimates, but they are also neglecting sublethal assessments. China and India in Asia, as well as Brazil in the Americas, were responsible for most studies. The majority of the papers used stored grain insects as experimental models, which limits the applicability and representativeness of the findings. As a result, the main modes of exposure tested were fumigation and contact, which leads to the prevalence of estimates of lethal concentration in these studies. Therefore, a broader range of insect species deserves testing, with suitable modes of exposure identifying and characterizing the main molecules responsible for the insecticidal activity, which is seldom performed. Attention to these needs will circumvent current biases and allow the recognition of the main patterns of association between the origin and structure of phytochemicals and their insecticidal effects.
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DOI：
10.1016/j.coesh.2022.100371
发表时间：
2022-08-01
影响因子：
--
作者：
Guedes, Raul Narciso C.;Benelli, Giovanni;Agathokleous, Evgenios
通讯作者：
Agathokleous, Evgenios
影响因子：
4.6
作者：
Guedes, Raul Narciso C.;Rix, Rachel R.;Cutler, G. Christopher
通讯作者：
Cutler, G. Christopher
影响因子：
5.9
作者：
Agostini, M. Gabriela;Roesler, Ignacio;Bilenca, David
通讯作者：
Bilenca, David
影响因子：
4.1
作者：
Gerwick, B. Clifford;Sparks, Thomas C.
通讯作者：
Sparks, Thomas C.
影响因子：
2.9
作者：
HAIRSTON, NG;SMITH, FE;SLOBODKIN, LB
通讯作者：
SLOBODKIN, LB