KIR2DL5: An Orphan Inhibitory Receptor Displaying Complex Patterns of Polymorphism and Expression.
KIR2DL5: An Orphan Inhibitory Receptor Displaying Complex Patterns of Polymorphism and Expression.
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DOI：
10.3389/fimmu.2012.00289
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发表时间：
2012
影响因子：
7.3
通讯作者：
Vilches C
中科院分区：
文献类型：
--
作者：
Cisneros E;Moraru M;Gómez-Lozano N;López-Botet M;Vilches C
最近开发的抗KIR 2DL 5（CD 158 f）抗体已经证明了NK和T淋巴细胞表面上的KIR 2DL 5表达，使其成为人类基因组中鉴定的最后一个功能性KIR。KIR 2DL 5属于具有D 0-D2型Ig样结构域的KIR的祖先谱系，其中KIR 2DL 4（HLA-G受体）是唯一的其他人类成员。尽管KIR 2DL 4和KIR 2DL 5由具有相似结构域使用的基因编码，但几种KIR 2DL 5功能更接近KIR识别经典HLA I类分子的功能-表面表达的KIR 2DL 5通过SHP-2磷酸酶抑制NK细胞，并在NK和T淋巴细胞上显示克隆分布。在任何物种中均未描述KIR 2DL 5的激活同源物。KIR 2DL 5的遗传学是复杂的，因为它的基因在10170万年前的现代人类祖先中重复。两个KIR 2DL 5旁系同源物都经历了等位基因多样化;着丝粒基因最常由等位基因代表，其表达通过DNA甲基化在表观遗传学上沉默，从而提供了研究KIR转录调控的天然系统。KIR 2DL 5在免疫中的作用尚未完全了解，尽管有不同的尝试来定义其配体。在这里，我们重新审视了KIR 2DL 5的最相关特征，KIR 2DL 5是一种NK细胞受体，具有独特的遗传、结构和功能特征。
A recently developed anti-KIR2DL5 (CD158f) antibody has demonstrated KIR2DL5 expression on the surface of NK and T lymphocytes, making it the last functional KIR identified in the human genome. KIR2DL5 belongs to an ancestral lineage of KIR with Ig-like domains of the D0-D2 type, of which KIR2DL4, an HLA-G receptor, is the only other human member. Despite KIR2DL4 and KIR2DL5 being encoded by genes with similar domain usage, several KIR2DL5 functions resemble more closely those of KIR recognizing classical HLA class I molecules – surface-expressed KIR2DL5 inhibits NK cells through the SHP-2 phosphatase and displays a clonal distribution on NK and T lymphocytes. No activating homolog of KIR2DL5 has been described in any species. The genetics of KIR2DL5 is complicated by duplication of its gene in an ancestor of modern humans living ∼1.7 million years ago. Both KIR2DL5 paralogs have undergone allelic diversification; the centromeric gene is most often represented by alleles whose expression is silenced epigenetically through DNA methylation, thus providing a natural system to investigate the regulation of KIR transcription. The role of KIR2DL5 in immunity is not completely understood, in spite of different attempts to define its ligand. Here we revisit the most relevant characteristics of KIR2DL5, an NK-cell receptor possessing a unique combination of genetic, structural, and functional features.
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长臂猿中 MHC-C 和 MHC-G 的缺失伴随着一个小的、可变的和不规则的杀伤细胞 Ig 样受体位点。
DOI：
10.4049/jimmunol.0903016
发表时间：
2010-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Abi-Rached L;Kuhl H;Roos C;ten Hallers B;Zhu B;Carbone L;de Jong PJ;Mootnick AR;Knaust F;Reinhardt R;Parham P;Walter L
通讯作者：
Walter L
影响因子：
4.4
作者：
Hershberger, KL;Shyam, R;Letvin, NL
通讯作者：
Letvin, NL
影响因子：
32.4
作者：
Khakoo, SI;Rajalingam, R;Parham, P
通讯作者：
Parham, P
影响因子：
9.1
作者：
Jiao, Yu-Lian;Zhang, Bing-Chang;Zhao, Yue-Ran
通讯作者：
Zhao, Yue-Ran
DOI：
10.1084/jem.20021127
发表时间：
2003-01-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chan HW;Kurago ZB;Stewart CA;Wilson MJ;Martin MP;Mace BE;Carrington M;Trowsdale J;Lutz CT
通讯作者：
Lutz CT