Circadian rhythms and mood regulation: insights from pre-clinical models.
Circadian rhythms and mood regulation: insights from pre-clinical models.
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DOI：
10.1016/j.euroneuro.2011.07.008
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发表时间：
2011-09
影响因子：
5.6
通讯作者：
McClung, Colleen A.
中科院分区：
文献类型：
--
作者：
McClung, Colleen A.
重度抑郁症、双相情感障碍和季节性情感障碍等情感障碍与昼夜节律的严重破坏有关。事实上，睡眠/觉醒周期的改变是 DSM IV 诊断的一个关键特征，并且用于治疗这些疾病的几种疗法对人类的节律长度和稳定性具有深远的影响。此外，多项人类遗传学研究已经确定了与这些疾病相关的特定昼夜节律基因的多态性。因此，昼夜节律系统和情绪调节之间似乎存在很强的关联，尽管这种关联背后的机制尚不清楚。最近，许多动物模型研究已经开始揭示昼夜节律基因和情绪相关神经递质系统之间复杂的相互作用、光操纵对大脑回路的影响、慢性压力对节律的影响，以及抗抑郁药和情绪稳定药物改变生物钟的方式。本综述将重点关注从使用临床前模型中收集到的最新进展，以进一步了解昼夜节律系统如何调节情绪。
Affective disorders such as major depression, bipolar disorder, and seasonal affective disorder are associated with major disruptions in circadian rhythms. Indeed, altered sleep/wake cycles are a critical feature for diagnosis in the DSM IV and several of the therapies used to treat these disorders have profound effects on rhythm length and stabilization in human populations. Furthermore, multiple human genetic studies have identified polymorphisms in specific circadian genes that associate with these disorders. Thus, there appears to be a strong association between the circadian system and mood regulation, although the mechanisms that underlie this association are unclear. Recently, a number of studies in animal models have begun to shed light on the complex interactions between circadian genes and mood-related neurotransmitter systems, the effects of light manipulation on brain circuitry, the impact of chronic stress on rhythms, and the ways in which antidepressant and mood-stabilizing drugs alter the clock. This review will focus on the recent advances that have been gleaned from the use of pre-clinical models to further our understanding of how the circadian system regulates mood.
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影响因子：
2.7
作者：
Einat, Haim;Kronfeld-Schor, Noga;Eilam, David
通讯作者：
Eilam, David
影响因子：
15.9
作者：
Abizaid, Alfonso;Liu, Zhong-Wu;Horvath, Tamas L.
通讯作者：
Horvath, Tamas L.
昼夜节律的代谢和能量学的融合。
DOI：
10.1126/science.1195027
发表时间：
2010-12-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bass J;Takahashi JS
通讯作者：
Takahashi JS
影响因子：
6.1
作者：
Fitzgerald, Paul J.;Barkus, Chris;Feyder, Michael;Wiedholz, Lisa M.;Chen, Yi-Chyan;Karlsson, Rose-Marie;Machado-Vieira, Rodrigo;Graybeal, Carolyn;Sharp, Trevor;Zarate, Carlos;Harvey-White, Judith;Du, Jing;Sprengel, Rolf;Gass, Peter;Bannerman, David;Holmes, Andrew
通讯作者：
Holmes, Andrew
影响因子：
2.7
作者：
Ashkenazy, Tal;Einat, Haim;Kronfeld-Schor, Noga
通讯作者：
Kronfeld-Schor, Noga