Effect of caffeine on alcohol drinking in mice.
Effect of caffeine on alcohol drinking in mice.
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DOI：
10.1016/j.alcohol.2021.03.005
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Griffin WC
中科院分区：
文献类型：
--
作者：
Haun HL;Olsen ACK;Koch KE;Luderman LN;May CE;Griffin WC
将酒精（乙醇）与含咖啡因的饮料混合仍然是一种常见和危险的做法。能量饮料是一种含咖啡因的饮料，当用作混合物时，由于其相对高的咖啡因含量以及其高度甜味的风味特征，其可能特别成问题。本研究使用了一个小鼠模型的限制访问饮酒和lickometer电路，以检查能量饮料及其咖啡因含量对乙醇消耗的影响。可以预见的是，与纯乙醇溶液相比，高甜度能量饮料显著增加了乙醇摄入量（6.34±0.2 vs 5.01±0.3 g/kg; Cohen's d =1.79）。有趣的是，在普通乙醇溶液中掺入能量饮料中发现的相同浓度的咖啡因（无甜味剂）也增加了乙醇摄入量（5.47±0.3 vs 4.11±0.3 g/kg;科恩d =1.4）。较低浓度的咖啡因对酒精饮料没有影响。有趣的是，两种浓度的纯咖啡因溶液都引起了大量的瓶子接触，表明小鼠发现溶液可口。这些发现表明，添加咖啡因改变乙醇溶液的苦味可以以与使溶液变甜类似的方式增加摄入量。此外，研究结果强调了味道在刺激乙醇消费方面的重要性，以及咖啡因在这一过程中的潜在作用。
Mixing alcohol (ethanol) with caffeinated beverages continues to be a common and risky practice. Energy drinks are one type of caffeinated beverage that may be especially problematic when used as mixers due to their relatively high caffeine content in combination with their highly sweetened flavor profile. The present study used a mouse model of limited access drinking and lickometer circuitry to examine the effects of an energy drink and its caffeine content on ethanol consumption. Predictably, the highly sweetened energy drink significantly increased ethanol intake compared to a plain ethanol solution (6.34±0.2 vs 5.01±0.3 g/kg; Cohen’s d =1.79). Interestingly, adulterating a plain ethanol solution with the same concentration of caffeine (sans sweetener) found in the energy drink also increased ethanol intake (5.47±0.3 vs 4.11±0.3 g/kg; Cohen’s d =1.4). A lower concentration of caffeine was without effect on ethanol drinking. Interestingly, plain caffeine solutions at both concentrations tested provoked high numbers of bottle contacts indicating that the mice found the solution palatable. These findings suggest that altering the bitterness profile of an ethanol solution with the addition of caffeine can drive up intake in a similar manner as sweetening the solution. Further, the findings underscore the importance of taste in motivating ethanol consumption and the potential role that caffeine can have in this process.
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影响因子：
3.4
作者：
Griffin, William C., III;Lopez, Marcelo F.;Yanke, Amy B.;Middaugh, Lawrence D.;Becker, Howard C.
通讯作者：
Becker, Howard C.
影响因子：
3.6
作者：
Hilbert, Megan L. T.;May, Christina E.;Griffin, William C., III
通讯作者：
Griffin, William C., III
影响因子：
2.9
作者：
Griffin, William C., III;Middaugh, Lawrence D.;Becker, Howard C.
通讯作者：
Becker, Howard C.
影响因子：
3.2
作者：
Arria, Amelia M.;Caldeira, Kimberly M.;O'Grady, Kevin E.
通讯作者：
O'Grady, Kevin E.
影响因子：
3.4
作者：
Griffin, William C., III;McGovern, Robin W.;Bell, Guinevere H.;Randall, Patrick K.;Middaugh, Lawrence D.;Patrick, Kennerly S.
通讯作者：
Patrick, Kennerly S.