Stress-Induced Transcriptomic Changes in Females with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Reveal Disrupted Immune Signatures.
Stress-Induced Transcriptomic Changes in Females with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Reveal Disrupted Immune Signatures.
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在患有肌肉痛脑脊髓炎/慢性疲劳综合征的女性中，应激诱导的转录变化揭示了免疫信号的紊乱。
DOI：
10.3390/ijms24032698
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发表时间：
2023-01-31
影响因子：
5.6
通讯作者：
Nathanson, Lubov
中科院分区：
文献类型：
--
作者：
Van Booven, Derek J. J.;Gamer, Jackson;Joseph, Andrew;Perez, Melanie;Zarnowski, Oskar;Pandya, Meha;Collado, Fanny;Klimas, Nancy;Oltra, Elisa;Nathanson, Lubov
关键词：
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, complex multi-organ illness characterized by unexplained debilitating fatigue and post-exertional malaise (PEM), which is defined as a worsening of symptoms following even minor physical or mental exertion. Our study aimed to evaluate transcriptomic changes in ME/CFS female patients undergoing an exercise challenge intended to precipitate PEM. Our time points (baseline before exercise challenge, the point of maximal exertion, and after an exercise challenge) allowed for the exploration of the transcriptomic response to exercise and recovery in female patients with ME/CFS, as compared to healthy controls (HCs). Under maximal exertion, ME/CFS patients did not show significant changes in gene expression, while HCs demonstrated altered functional gene networks related to signaling and integral functions of their immune cells. During the recovery period (commonly during onset of PEM), female ME/CFS patients showed dysregulated immune signaling pathways and dysfunctional cellular responses to stress. The unique functional pathways identified provide a foundation for future research efforts into the disease, as well as for potential targeted treatment options.
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DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
影响因子：
--
作者：
Brenu, E W;Hardcastle, S L;Atkinson, G M;van Driel, M L;Kreijkamp-Kaspers, S;Ashton, K J;Staines, D R;Marshall-Gradisnik, S M
通讯作者：
Marshall-Gradisnik, S M
影响因子：
2.6
作者：
Chu, Lily;Valencia, Ian J.;Montoya, Jose G.
通讯作者：
Montoya, Jose G.
影响因子：
3.7
作者：
Bouquet, Jerome;Li, Tony;Chiu, Charles Y.
通讯作者：
Chiu, Charles Y.
影响因子：
11
作者：
Hornig, M.;Gottschalk, G.;Lipkin, W. I.
通讯作者：
Lipkin, W. I.