Human Platelets and Influenza Virus: Internalization and Platelet Activation.

Human Platelets and Influenza Virus: Internalization and Platelet Activation.
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DOI:
10.1080/09537104.2021.1961710
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发表时间:
2022-02-17
期刊:
影响因子:
3.3
通讯作者:
Koupenova M
Koupenova M
中科院分区:
医学3区
文献类型:
--
作者:
Bote J;Corkrey HA;Koupenova M

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长期以来,流感感染与患者的血栓前结局相关,血小板是主要负责血栓形成的血液成分。在这篇综述中,我们概述了已知的流感与人类血小板,病毒粒子内化和病毒RNA传感的相互作用,以及随之而来的对血小板功能的影响。我们进一步讨论了IgG-流感复合物对血小板的激活作用,并触及了感染期间与患者血栓前结局相关的环境血小板激活机制。
Influenza infection has long been associated with prothrombotic outcomes in patients and platelets are the blood component predominantly responsible for thrombosis. In this review, we outline what is known about influenza interaction with human platelets, virion internalization and viral RNA sensing, and the consequent impact on platelet function. We further discuss activation of platelets by IgG-influenza complexes and touch upon mechanisms of environmental platelet activation that relate to prothrombotic outcomes in patients during infection.
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