Racial differences in cortical bone and their relationship to biochemical variables in Black and White children in the early stages of puberty.
Racial differences in cortical bone and their relationship to biochemical variables in Black and White children in the early stages of puberty.
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DOI：
10.1007/s00198-012-2174-8
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发表时间：
2013-06
影响因子：
4
通讯作者：
Lewis, R. D.
中科院分区：
文献类型：
--
作者：
Warden, S. J.;Hill, K. M.;Ferira, A. J.;Laing, E. M.;Martin, B. R.;Hausman, D. B.;Weaver, C. M.;Peacock, M.;Lewis, R. D.
关键词：
骨骼结构的种族差异可能根源于童年，因为骨骼大小主要在生长过程中形成。本研究旨在比较青春期早期黑人和白人儿童胫骨骨干内的皮质骨健康状况，并探讨生化变量在解释皮质骨特性的种族差异中的贡献。一项横断面研究比较了 314 名青春期早期参与者（n=155 名男性；n=164 名黑人）的胫骨骨干和生化变量的外周定量计算机断层扫描衍生的皮质骨测量值。与白人相比，黑人的皮质体积骨矿物质密度、质量和尺寸更大（均 p<0.01），导致黑人的胫骨强度（极性强度-应变指数 [SSIP]）高出 17.0%（p<0.001）。周转标记表明，黑人比白人具有更高的骨形成（骨钙素 [OC] 和骨特异性碱性磷酸酶）和更低的骨吸收（N 末端端肽）（所有 p<0.01）。黑人的 25-羟基维生素 D [25(OH)D] 也较低，1,25-二羟基维生素 D [1,25(OH)2D] 和甲状旁腺激素 (PTH) 较高（所有 p<0.05）。白人的胫骨特性与 25(OH)D 和 PTH 之间不存在相关性（均 p≥0.10）；然而，在黑人中，SSIP 分别与 25(OH)D 和 PTH 呈负相关和正相关（均 p≤0.02）。种族引起的骨横截面积和 SSIP 的变化部分可以通过胫骨长度、25(OH)D/PTH 和 OC 来解释。黑人和白人胫骨皮质骨特性的差异是在青春期早期确立的，黑人儿童的皮质骨特性增强可能是由于较高的 PTH 和 OC 所致。
Racial differences in bone structure likely have roots in childhood as bone size develops predominantly during growth. This study aimed to compare cortical bone health within the tibial diaphysis of black and white children in the early stages of puberty, and explore the contributions of biochemical variables in explaining racial variation in cortical bone properties. A cross-sectional study was performed comparing peripheral quantitative computed tomography-derived cortical bone measures of the tibial diaphysis and biochemical variables in 314 participants (n=155 males; n=164 blacks) in the early stages of puberty. Blacks had greater cortical volumetric bone mineral density, mass and size compared to whites (all p<0.01), contributing to blacks having 17.0% greater tibial strength (polar strength-strain index [SSIP]) (p<0.001). Turnover markers indicated blacks had higher bone formation (osteocalcin [OC] and bone specific alkaline phosphatase) and lower bone resorption (N-terminal telopeptide) than whites (all p<0.01). Blacks also had lower 25-hydroxyvitamin D [25(OH)D], and higher 1,25-dihydroxyvitamin D [1,25(OH)2D] and parathyroid hormone (PTH) (all p<0.05). There were no correlations between tibial bone properties, and 25(OH)D and PTH in whites (all p≥0.10); however, SSIP was negatively and positively correlated with 25(OH)D and PTH in blacks, respectively (all p≤0.02). Variation in bone cross-sectional area and SSIP attributable to race was partially explained by tibial length, 25(OH)D/PTH and OC. Divergence in tibial cortical bone properties between blacks and whites is established by the early stages of puberty with the enhanced cortical bone properties in black children possibly being explained by higher PTH and OC.
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影响因子：
5.8
作者：
Leonard, Mary B.;Elmi, Angelo;Zemel, Babette S.
通讯作者：
Zemel, Babette S.
影响因子：
5.8
作者：
LUCKEY, MM;MEIER, DE;GOLDSMITH, SJ
通讯作者：
GOLDSMITH, SJ
DOI：
10.1111/j.1532-5415.2005.53101.x
发表时间：
2005-02-01
影响因子：
6.3
作者：
Cauley, JA;Lui, LY;Ensrud, KE
通讯作者：
Ensrud, KE
影响因子：
6.2
作者：
Cauley, Jane A.;Wu, LieLing;Robbins, John
通讯作者：
Robbins, John
影响因子：
7.1
作者：
Braun, Michelle;Palacios, Cristina;Weaver, Connie M.
通讯作者：
Weaver, Connie M.