Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging.
Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging.
复制标题
DOI：
10.1136/bjo.2008.138172
复制
发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Yücel YH
中科院分区：
文献类型：
--
作者：
Gupta N;Greenberg G;de Tilly LN;Gray B;Polemidiotis M;Yücel YH
目的：在活体条件下，研究青光眼和视力丧失患者的外侧膝状体核（LGN）是否发生萎缩。在机构St Michael's Hospital研究伦理委员会批准后，对影响双眼的视野缺损的青光眼患者（n = 10）和年龄匹配的对照组（n = 8）进行了前瞻性和盲态神经影像学研究。 在知情同意后，所有受试者均接受了1.5特斯拉MRI。获得两个LGN的冠状质子密度磁共振图像，并由三名对诊断不知情的神经放射科医生一致测量LGN高度。使用t检验比较青光眼组和对照组。通过1.5特斯拉MRI对每名受试者的两个LGN进行识别和可视化。与对照组相比，青光眼患者右侧和左侧LGN的平均LGN高度降低（分别为4.09（0.89）mm vs 4.74（0.54）mm，p>0.05）和3.98（0.57）mm vs 4.83（0.95）mm; p = 0.033）。 与对照组相比，青光眼患者的合并右侧和左侧LGN高度显著降低（8.07（1.06）mm vs 9.56（0.86）mm; p = 0.005）。 人青光眼中LGN变性的体内MRI证据与离体灵长类动物和人神经病理学研究一致。LGN萎缩可能是某些青光眼患者视觉系统损伤和/或进展的相关生物标志物。
To determine in vivo whether the lateral geniculate nucleus (LGN) undergoes atrophy in patients with glaucoma and vision loss compared with normal subjects. Following institutional St Michael’s Hospital Research Ethics Board approval, a prospective and masked neuroimaging study was conducted on glaucoma patients with visual-field defects affecting both eyes (n = 10) and age-matched controls (n = 8). Following informed consent, all subjects underwent 1.5-Tesla MRI. Coronal proton density magnetic resonance images of both LGNs were obtained, and LGN height measurements were measured by consensus by three neuroradiologists masked to the diagnosis. Glaucoma and control groups were compared using the t test. Both LGNs were identified and visualised by 1.5-Tesla MRI for every subject. Compared with controls, the mean LGN heights in glaucoma were decreased in right (4.09 (0.89) mm vs 4.74 (0.54) mm, p>0.05) and left LGNs (3.98 (0.57) mm vs 4.83 (0.95) mm; p = 0.033). The combined right and left LGN height in glaucoma was significantly decreased compared with controls (8.07 (1.06) mm vs 9.56 (0.86) mm; p = 0.005). In vivo MRI evidence of LGN degeneration in human glaucoma is consistent with ex vivo primate and human neuropathological studies. LGN atrophy may be a relevant biomarker of visual system injury and/or progression in some glaucoma patients.
登录
查看更多内容
影响因子：
1.9
作者：
Saeki, N;Fujimoto, N;Yamaura, A
通讯作者：
Yamaura, A
影响因子：
11
作者：
SCHELTENS, P;LEYS, D;VALK, J
通讯作者：
VALK, J
影响因子：
17.8
作者：
Yücel, YH;Zhang, QA;Gupta, N
通讯作者：
Gupta, N
DOI：
10.1016/s0008-4182(06)80033-5
发表时间：
2006-10-01
影响因子：
4.2
作者：
Baker, Chad F.;Jeerakathil, Thomas;Climenhaga, Harold W.
通讯作者：
Climenhaga, Harold W.
影响因子：
3.3
作者：
PERRY, VH;OEHLER, R;COWEY, A
通讯作者：
COWEY, A