Selection of vaccine strains for serotype O foot-and-mouth disease viruses (2007-2012) circulating in Southeast Asia, East Asia and Far East.
Selection of vaccine strains for serotype O foot-and-mouth disease viruses (2007-2012) circulating in Southeast Asia, East Asia and Far East.
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DOI：
10.1016/j.vaccine.2017.10.099
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发表时间：
2017-12-18
期刊：
影响因子：
5.5
通讯作者：
Parida S
中科院分区：
文献类型：
--
作者：
Mahapatra M;Upadhyaya S;Aviso S;Babu A;Hutchings G;Parida S
口蹄疫（Foot-and-mouth disease，FMD）是东南亚（Southeast Asia，SEA）和东亚的地方性疾病，具有多种血清型和每种血清型内的多种基因型的病毒循环。尽管远东的日本和韩国等国家没有口蹄疫，但在2010年，记录了口蹄疫血清型O（O/Mya-98）的爆发，此后，尽管定期接种疫苗，韩国仍经历了几次口蹄疫爆发。在这项研究中，从2007年至2012年从SEA、东亚和远东分离的总共85种血清型O型FMD病毒（FMDV）通过使用4种现有疫苗株（O/HKN/6/83、O/IND/R2/75、O/SKR/2010和O/PanAsia-2）和1种推定疫苗株（O/MYA/2009）的抗血清进行病毒中和试验，并通过全衣壳测序进行表征。血清学研究显示与疫苗株具有广泛的交叉反应性; O/PanAsia-2与95.3%、O/HKN/6/83与91.8%、O/IND/R2/75与80%以及本研究中采用的假定菌株O/MYA/2009与89.4%分离株表现出良好的匹配性。类似地，O/PanAsia-2和O/IND/R2/75疫苗显示出与属于O-Ind-2001 d亚系的所有8种病毒的良好匹配，而O/Mya-98谱系、O/MYA/2009和O/SKR/2010的疫苗显示出最低匹配，表明它们不适合保护感染O-Ind-2001 d病毒。衣壳序列数据的贝叶斯分析表明，这些循环病毒（n = 85）是SEA或中东-南亚（ME-SA）拓扑型。ME-SA拓扑型病毒主要在老挝人民民主共和国、越南、缅甸和泰国发现，反映了与印度次大陆的贸易联系，也在东南亚国家内发现。这些结果的背景下，在东南亚和东亚国家的口蹄疫控制的影响进行了讨论。
Foot-and-mouth disease (FMD) is endemic in Southeast Asia (SEA) and East Asia with circulation of multiple serotypes and multiple genotypes within each serotype of the virus. Although countries like Japan and South Korea in the Far East were free of FMD, in 2010 FMD serotype O (O/Mya-98) outbreaks were recorded and since then South Korea has experienced several FMD outbreaks despite regular vaccination. In this study a total of 85 serotype O FMD viruses (FMDV) isolated from 2007 to 2012 from SEA, East Asia and Far East were characterized by virus neutralisation tests using antisera to four existing (O/HKN/6/83, O/IND/R2/75, O/SKR/2010 and O/PanAsia-2) and one putative (O/MYA/2009) vaccine strains, and by full capsid sequencing. Serological studies revealed broad cross-reactivity with the vaccine strains; O/PanAsia-2 exhibited a good match with 95.3%, O/HKN/6/83 with 91.8%, O/IND/R2/75 with 80%, and the putative strain O/MYA/2009 with 89.4% isolates employed in this study. Similarly O/PanAsia-2 and O/IND/R2/75 vaccines showed a good match with all eight viruses belonging to O-Ind-2001d sublineage whereas the vaccines of O/Mya-98 lineage, O/MYA/2009 and O/SKR/2010 exhibited the lowest match indicating their unsuitability to protect infections from O-Ind-2001d viruses. A Bayesian analysis of the capsid sequence data indicated these circulating viruses (n = 85) to be of either SEA or Middle East-South Asian (ME-SA) topotype. The ME-SA topotype viruses were mainly detected in Lao PDR, Vietnam, Myanmar and Thailand reflecting the trade links with the Indian subcontinent, and also within the SEA countries. Implications of these results in the context of FMD control in SEA and East Asian countries are discussed.
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